Generic
Tropicamide + Phenylephrine + Lidocaine
1 brands available in the market
At a glance
Tropicamide + Phenylephrine + Lidocaine is indicated for cataract surgery to obtain mydriasis and intraocular anesthesia during the surgical procedure.
Description
This combination contains Tropicamide (antimuscarinic), Phenylephrine (α-adrenergic agonist), and Lidocaine (local anesthetic). Tropicamide and phenylephrine produce mydriasis, while lidocaine provides intraocular anesthesia.
Indications
- Mydriasis and intraocular anesthesia during cataract surgery
Pharmacological class
Mydriatic + Vasoconstrictor + Local Anesthetic
Pharmacology
Tropicamide is an antimuscarinic that relaxes the sphincter muscle of the iris, causing pupillary dilatation. Phenylephrine is an α-adrenergic agonist that stimulates the dilator muscle, causing pupillary dilatation. Lidocaine blocks sodium channels, providing local anesthesia.
Mechanism of action
Produces mydriasis (tropicamide + phenylephrine) and intraocular anesthesia (lidocaine).
Dosage
Adult Dose (Intracameral):
- For cataract surgery: 0.2 ml as a single injection via intracameral route through the side port or principal port
- Instill 1-2 drops of anesthetic eye drops 5 minutes before surgery
Administration
- Administered only by an ophthalmic surgeon
- Under local anesthesia, at the beginning of cataract surgery
- Open under aseptic conditions only
- Use immediately after opening; do not reuse for the other eye or any other patient
Missed dose
If you miss a dose, consult your doctor.
Drug interactions
No known significant interactions.
Food interactions
Food interactions are not significant.
Contraindications
- Hypersensitivity to any component
Side effects
Common Side Effects:
- Injury to the lens (posterior capsule rupture)
- Swelling of the retina (cystoid macular edema)
- Headache
- Swelling of the cornea (keratitis)
- Increased pressure in the eye
- Redness of the eye (ocular hyperaemia)
- High blood pressure (hypertension)
Use in pregnancy
Use in Pregnancy: Should not be used during pregnancy.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Use in lactation
Use in Lactation: Should not be used during lactation.
Precautions & warnings
- Do not use if blister is damaged or broken
- Open under aseptic conditions only
- Use immediately after opening
- Not recommended in: combined cataract surgery with vitrectomy, shallow anterior chamber, history of acute narrow angle glaucoma
- Doctor should consider patient's medical condition if suffering from hypertension, atherosclerosis, heart disease, hyperthyroidism, prostate gland disorders, epilepsy, liver or kidney problem, breathing problem or myasthenia gravis
Pediatric use
Safety and efficacy not established in children
Geriatric use
Only for elderly and adults undergoing cataract surgery
Renal / hepatic impairment
Renal Impairment: Not applicable (ophthalmic application)
Hepatic Impairment: Not applicable (ophthalmic application)
Overdose effects
Overdose is not applicable (single dose in surgery).
Therapeutic class
Other ophthalmic preparations
Storage conditions
Do not store above 30°C. Does not require refrigeration. Keep away from light and out of reach of children. For single eye use only. Use immediately after first opening. Discard remaining solution appropriately.