Acemox250mg

Acetazolamide is a carbonic anhydrase inhibitor that reduces intraocular pressure in glaucoma and serves as an adjuvant treatment for edema and seizures.

Indicated in open angle glaucoma, secondary glaucoma, and as an adjuvant in the treatment of edema and epilepsy.

Carbonic anhydrase inhibitor

Carbonic Anhydrase Inhibitor & Sulfonamide Derivative

Acetazolamide inhibits carbonic anhydrase enzyme, decreasing the secretion of aqueous humor in the eye and dropping intraocular pressure. In the CNS, it retards abnormal paroxysmal neuronal discharges.

Inhibition of carbonic anhydrase results in reduced hydrogen ion secretion at renal tubules and decreased aqueous humor formation in ciliary bodies of the eye.

Adults: Initially 250 mg (1 tablet) 4 times daily. Acute intraocular pressure: 2 tablets (500 mg) initially followed by 1 tablet every 6 hours. Children: 0.5 to 2 tablets in divided doses.

Administer orally with water, preferably with meals to lessen GI distress.

Take as soon as remembered unless it is almost time for the next scheduled dose. Do not take double doses.

Common: Headache, drowsiness, dizziness, fatigue, anorexia, polyuria, insomnia, gastrointestinal upset, and paresthesia.

Monitor serum electrolytes for hypokalemia or hyponatremia and observe for metabolic acidosis during long-term therapy.

Contraindicated in marked kidney/liver dysfunction, decreased blood sodium/potassium levels, hyperchloremic acidosis, and chronic noncongestive angle closure glaucoma.

Increased risk of hypokalemia with other diuretics. May increase plasma levels of phenytoin, carbamazepine, and digitalis glycosides.

Taking with food helps reduce gastrointestinal irritation.

Pregnancy Category C. Use only if clearly needed and benefits outweigh potential risks to fetus.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Excreted in small amounts in human milk; caution should be exercised when administered to a nursing woman.

Dose must be carefully titrated based on body weight/age under specialist supervision.

Elderly patients are more susceptible to electrolyte imbalance and metabolic acidosis.

Contraindicated in severe renal impairment (CrCl < 10 mL/min) and severe hepatic insufficiency.

Overdose may cause electrolyte imbalance, metabolic acidosis, and CNS effects. Treatment is supportive.

Store below 30°C. Protect from light and moisture. Keep out of reach of children.

Acetazolamide (C4H6N4O3S2)

Question: How does Acetazolamide help in glaucoma? Answer: It decreases the production of aqueous humor fluid in the eye, which lowers high intraocular pressure. Question: Why does Acetazolamide increase urination? Answer: As a carbonic anhydrase inhibitor, it promotes the excretion of sodium, potassium, and water through urine.