Amilin Max

Moderate to severe depression associated with moderate to severe anxiety; insomnia, feelings of guilt or worthlessness, agitation, psychic and somatic anxiety, suicidal ideation, anorexia.

Amitriptyline is a tricyclic antidepressant that inhibits norepinephrine and serotonin reuptake in the brain, producing antidepressant activity. Chlordiazepoxide is an anxiolytic that enhances GABA-mediated chloride influx through GABA receptor channels, causing membrane hyperpolarization and producing sedative and anxiolytic effects.

Initial dose: 3-4 tablets daily in divided doses. The larger portion of the total daily dose may be taken at bedtime. In some patients, a single dose at bedtime may be sufficient. Maintenance: Reduce to the smallest effective dose.

Common side effects: Drowsiness, dry mouth, constipation, blurred vision, dizziness, bloating, fatigue, weakness, restlessness, lethargy, weight gain, confusion, difficulty in urination, orthostatic hypotension, increased heart rate, uncoordinated movements, memory impairment. Rare: Vivid dreams, impotence, tremor, nasal congestion.

Pregnancy Category: D. Amitriptyline + Chlordiazepoxide is unsafe during pregnancy; definite evidence of risk to the fetus. Use only if clearly needed with medical advice.

Pregnancy Category: D — always consult a doctor before taking during pregnancy.

Do not stop suddenly without consulting your doctor (withdrawal symptoms may occur). Caution while driving (drowsiness, dizziness, blurred vision). Avoid alcohol completely. Caution in liver disease; dose adjustment may be needed. Caution in patients with history of seizures. Inform doctor if you experience suicidal thoughts or unusual mood changes. Do not use during pregnancy and breastfeeding.

Overdose symptoms: cardiac arrhythmias, severe hypotension, convulsions, coma, confusion, diminished reflexes. Treatment: symptomatic and supportive measures, ECG monitoring.

Store in a cool and dry place, protected from light. Keep out of reach of children.