Antogin ER 500

Ranolazine is a medicine used for the management of angina (heart-related chest pain). It helps to prevent new attacks of angina, but it does not stop an acute attack, once it has started. It relieves chest pain by making the heart work more efficiently. Ranolazine should be taken in the dose as advised by your doctor, at the same time each day. It should be taken with food to avoid stomach upset. Your doctor will decide how often you should take this medicine. This may change from time to time depending on how well it is working. You should take this medicine regularly to get the most benefit, even if you feel fine. It is preventing future harm. If you stop taking it, your chest pain may come back. You can improve the health of your heart by making some lifestyle changes such as quitting smoking, cutting down on alcohol, eating well, taking regular exercise and managing stress. Some common side effects of this medicine include nausea, vomiting, headache, dizziness, constipation, and weakness. Talk to your doctor if these bother you or do not go away. This is not suitable for some people. Tell your doctor if you are suffering from any liver or kidney problems. Also let your doctor know all other medications you are using as some may affect, or be affected by this medicine. This medicine is not usually recommended during pregnancy or breastfeeding. Ranolazine is an anti-anginal medication. It works by decreasing the oxygen requirement of the heart by relaxing heart muscle.

• Angina (heart-related chest pain)

Ranolazine exert its antianginal and anti-ischaemic effects through concentration-, voltage-, and frequency-dependent inhibition of the late Na current and other cardiac ion channels and transporters. It may decrease the magnitude of the late Na current resulting in a net reduction in intracellular Na concentrations, reversal of Ca overload, restoration of ventricular pump function, and prevention of ischaemia-induced arrhythmias. Its antianginal effects are not dependent upon reductions in heart rate or BP and QT interval prolongation effect is caused by inhibition of rapid delayed rectifier K current (IKr), which prolongs the ventricular action potential.

Adult Dose: Oral Chronic angina 500 mg PO BID initially; may increase to 1,000 mg PO BID, if needed Hepatic Impairment: Mild: Dose titration needed. Moderate to severe: Contraindicated. Renal Dose: Renal Impairment Mild to moderate (CrCl 30-80 mL/min): Dose titration needed. Severe (CrCl <30 mL/min): Contraindicated.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Ranolazine is to be taken with food.

If you miss a dose of Ranolazine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Nausea • Vomiting • Headache • Dizziness • Constipation • Weakness

[CONSULT YOUR DOCTOR] It is not known whether Ranolazine alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. It should be taken with food to avoid stomach upset. It improves HbA1c and blood sugar levels in diabetes patients. It may cause dizziness or sleepiness. Do not drive or do anything requiring concentration until you know how it affects you. Notify your doctor if you are taking any other medications along with Ranozex Tablet ER It may produce changes in the ECG (QTc interval prolongation). It is recommended to get an ECG done within 1 to 2 weeks of starting the medication.

Taking strong inhibitors of CYP3A (e.g., ketoconazole, clarithromycin, nelfinavir) Taking inducers of CYP3A (e.g., phenobarbital, rifampicin)Significant hepatic impairment

Increased plasma levels w/ moderate CYP3A4 inhibitors (e.g. diltiazem, fluconazole, erythromycin), P-glycoprotein inhibitors (e.g. verapamil, ciclosporin) and CYP2D6 inhibitors (e.g. paroxetine). May increase plasma digoxin concentrations. May increase risk of rhabdomyolysis w/ simvastatin. May increase plasma concentrations of atorvastatin, other statins (e.g. lovastatin) and CYP3A4 substrates w/ narrow therapeutic range (e.g. tacrolimus, sirolimus, everolimus). May increase plasma exposure of metformin. Increased risk of ventricular arrhythmias w/ other drugs that prolong QT interval (e.g. terfenadine, astemizole, mizolastine). Potentially Fatal: Increased plasma concentrations leading to increased adverse effects w/ CYP3A4 inhibitors (e.g. itraconazole, ketoconazole, HIV protease inhibitors, clarithromycin, telithromycin, nefazodone). Decreased plasma concentration w/ CYP3A4 inducers (e.g. rifampicin, phenytoin, phenobarbital, carbamazepine). Increased risk of QT interval prolongation w/ class 1A (e.g. quinidine) or class III (e.g. dofetilide, sotalol) antiarrhythmics other than amiodarone.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Ranolazine. Please consult your doctor.

[CONSULT YOUR DOCTOR] Ranolazine may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[CONSULT YOUR DOCTOR] Ranolazine is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

[CAUTION] Ranolazine should be used with caution in patients with kidney disease. Dose adjustment of Ranolazine may be needed. Please consult your doctor. Use of Ranolazine is not recommended in patients with severe kidney disease. [CAUTION] Ranolazine should be used with caution in patients with liver disease. Dose adjustment of Ranolazine may be needed. Please consult your doctor. Use of Ranolazine is not recommended in patients with moderate to severe liver disease.

What is heart attack? When heart attack coming? Related to chest pain angina commonly Chest pain headache vetrigo Angina pain Get echo n ECG done Chest pain headache virtigo Angina pain Get ECG n echo done Pain in chest and just behind that portion also. Visit ur physician firstChest pain could be because heart problems I am having chest pain in left side also in left arm Is this pain related to heart attack in any case?? Get ECG n echo done Pain in below heart area Is it gastric ? Or heart related? Get ecg echo tmt done to rule out cardiac problem for gastric can take pantocid dsr empty stomach