৳ 11/unit
Pack: ৳ 11
৳ 11/unit
Pack: ৳ 11
At a glance
Diclofenac Sodium + Misoprostol is a combination medication used for the treatment of osteoarthritis and rheumatoid arthritis in patients at high risk of developing NSAID-induced gastric and duodenal ulcers.
Indications
- Osteoarthritis (patients at high risk of NSAID-induced ulcers)
- Rheumatoid arthritis (patients at high risk of NSAID-induced ulcers)
Pharmacology
Diclofenac Sodium inhibits cyclooxygenase, reducing prostaglandin synthesis to decrease pain and inflammation. Misoprostol is a prostaglandin E1 analog that increases bicarbonate and mucous production in the gastric mucosa, preventing NSAID-induced ulcers.
Dosage
Osteoarthritis: 50 mg/200 mcg three times daily (max 200 mcg/dose, 800 mcg/day).
Rheumatoid arthritis: 50 mg/200 mcg three or four times daily (max 200 mcg/dose, 800 mcg/day).
If not tolerated, may reduce frequency to twice daily.
Side effects
Common (>10%): Rash (18%), pyrexia (15%), urticaria (13%), flushing (13%).
Occasional (1-10%): Hypertension (10%), hyperhidrosis (8%), cough (8%), tachypnea (8%), tachycardia (8%), anaphylaxis (7%), vomiting (5%), peripheral edema (3%), pruritus (3%).
Rare (<1%): Fatigue, atrial fibrillation, congestive heart failure, myocardial infarction, peptic ulcer, vaginitis, dysmenorrhea, alopecia.
Use in pregnancy
Pregnancy Category X. Contraindicated during pregnancy.
Pregnancy Category: X — always consult a doctor before taking during pregnancy.
Precautions & warnings
Caution in patients with inflammatory bowel disease or dehydration. The pharmacological activity in reducing fever and inflammation may diminish the utility of these diagnostic signs.
Overdose effects
Misoprostol overdose: convulsions, sedation, tremor, diarrhea, hypotension, bradycardia. Diclofenac overdose: lethargy, nausea, GI bleeding, acute renal failure, respiratory depression. Supportive treatment.
Storage conditions
Store in a cool and dry place below 25°C. Protect from light.