৳ 30/unit
Pack: ৳ 300
৳ 30/unit
Pack: ৳ 300
At a glance
Amisulpride is an atypical antipsychotic used for the treatment of acute and chronic schizophrenia. It selectively blocks dopamine D2 and D3 receptors to control both positive and negative symptoms.
Indications
Schizophrenia (acute and chronic) with prominent positive symptoms (delusions, hallucinations, thought disorders) and/or negative symptoms (blunted affect, social withdrawal).
Pharmacology
Amisulpride is an atypical antipsychotic that selectively binds to dopaminergic D2 and D3 receptors. It blocks pre-synaptic D2/D3 receptors to increase dopamine release. With low affinity for serotonin, alpha-adrenergic and histamine receptors, it causes fewer side effects compared to classical antipsychotics. It does not induce catalepsy and does not produce D2 hypersensitivity after repeated use.
Dosage
Oral: Acute psychotic episodes: 400-800 mg/day (divided doses), max 1200 mg/day. Mixed positive-negative symptoms: adjust based on positive symptom control. Predominant negative symptoms: 50-300 mg once daily. Elderly: dose reduction may be needed. Children (under 18): not recommended. Injection (PONV): Prevention: 5 mg IV (1-2 min) at anesthesia induction; Treatment: 10 mg IV (1-2 min) for nausea/vomiting.
Side effects
Common: Tremor, muscle stiffness or spasm, slow movement, excess saliva, restlessness, uncontrolled movements (head, neck, jaw or eyes), insomnia, anxiety, agitation, drowsiness, constipation, nausea, vomiting, dry mouth, weight gain, low blood pressure, dizziness, blurred vision, increased prolactin. Rare: Neuroleptic Malignant Syndrome (NMS), seizures, osteoporosis, aspiration pneumonia.
Use in pregnancy
Pregnancy Category: C. Safety of amisulpride during pregnancy has not been established; use only if clearly needed with medical advice.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Do not stop suddenly without consulting your doctor (withdrawal symptoms may occur). Caution while driving (drowsiness and dizziness). Avoid alcohol completely (increases CNS depression). Weight gain, blood sugar and cholesterol may increase; healthy diet and exercise are recommended. Dose adjustment needed in kidney disease. Do not use during pregnancy and breastfeeding.
Overdose effects
Overdose symptoms: drowsiness, sedation, hypotension, extrapyramidal symptoms, coma. Treatment: symptomatic and supportive measures.
Storage conditions
Store below 30C in a cool and dry place, protected from light. Keep out of reach of children.