osudhkosh
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Company•Beximco Pharmaceuticals Ltd.

Avastin

10mgRx
Generic: Simvastatin

৳ 15/unit

Pack: ৳ 150

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At a glance

Simvastatin is a statin used to lower high cholesterol and reduce the risk of heart disease. It inhibits HMG-CoA reductase, lowering LDL cholesterol and triglycerides while increasing HDL cholesterol.

Indications
  • Primary hypercholesterolemia (type IIa and IIb)
  • Coronary heart disease and elevated plasma cholesterol
  • High cholesterol
  • Prevention of heart attack and stroke
Pharmacology

Simvastatin inhibits HMG-CoA reductase in the liver, reducing cholesterol synthesis. This increases LDL receptor numbers on liver cells, enhancing LDL cholesterol removal from plasma. It also reduces VLDL cholesterol and increases HDL cholesterol.

Dosage

Adult Dose (Oral):

  • Hypercholesterolemia: Start 5-10 mg/day (evening); max 40 mg/day
  • High CV risk: Start 40 mg/day; adjust at 4-week intervals; max 80 mg/day
  • Homozygous FH: 40 mg/day (evening) or 80 mg/day in 3 divided doses
  • With dronedarone/verapamil/diltiazem: Do not exceed 10 mg/day
  • With amiodarone/amlodipine/ranolazine: Do not exceed 20 mg/day

Pediatric Dose (Heterozygous FH, 10-17 years):

  • Start 10 mg/day; increase at 4-week intervals; max 40 mg/day
Side effects

Common Side Effects:

  • Headache, fatigue, insomnia
  • Nausea, constipation/diarrhea, flatulence
  • Abdominal cramps, dyspepsia
  • Myalgia, myositis, myopathy
  • Rhabdomyolysis (rare)
  • Hepatitis, pancreatitis (rare)
Use in pregnancy

Use in Pregnancy: Highly unsafe (Category X); significant fetal harm; do not use during pregnancy or if planning pregnancy; consult your doctor.

Pregnancy Category: X — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Do not use in active liver disease or unexplained persistent transaminase elevations
  • Do not use in pregnancy or lactation
  • Chinese patients: Do not use 80 mg/day with niacin
  • Do not use with strong CYP3A4 inhibitors
  • Monitor for myopathy symptoms (muscle pain, weakness)
Overdose effects

No overdose data available; no specific antidote; provide general measures and monitor liver function.

Storage conditions

Store in a cool and dry place, protected from light; keep out of reach of children.

Simvastatin — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.