Azeflu

• Seasonal allergic rhinitis in patients 6 years of age and older

Azelastine Hydrochloride exhibits histamine H1-receptor antagonist activity in isolated tissues. The major metabolite, desmethylazelastine, also possesses H1-receptor antagonist activity.

Fluticasone Propionate is a synthetic trifluorinated corticosteroid with anti-inflammatory activity. Corticosteroids have been shown to have a wide range of effects on multiple cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, and lymphocytes) and mediators (e.g., histamine, eicosanoids, leukotrienes, and cytokines) involved in inflammation.

Adult: 1 spray each nostril twice daily.

Pediatric (6 years and older): 1 spray each nostril twice daily.

Important: The doctor will determine the duration and dosage. Dose may be adjusted as needed.

• Dysgeusia (metallic taste)
• Headache
• Epistaxis (nosebleeds)

[CONSULT YOUR DOCTOR] Azelastine + Fluticasone Nasal Spray may be unsafe during pregnancy (Category C). Animal studies have shown harmful effects on the developing baby. Use only if potential benefit justifies the risk.

• Caution when driving or operating machinery (may cause drowsiness or dizziness)
• Avoid alcohol or other CNS depressants
• Inform your doctor if you have infection, injury, or ulceration inside the nose
• Do not share the bottle with others
• Consult your doctor during pregnancy and breastfeeding

Azelastine overdose may cause increased somnolence. Chronic fluticasone overdose may cause symptoms of hypercorticism.

Store below 25°C. Protect from light. Do not store in the refrigerator. Keep out of reach of children.