Canarol 100
Rx- Generic:
- Canagliflozin
- Company:
- Drug International Ltd.
- Dosage form:
- Tablet
- Pack size:
- Strip (10 Tablet)
৳ 60/unit
Pack: ৳ 600
Price comparison
- This brand
- ৳ 60
- Cheapest of this genericCanaglif 100
- ৳ 40
The cheaper brand costs ৳ 20.00 less per unit
Compared against 4 brands
At a glance
Canagliflozin is an SGLT2 inhibitor used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. It reduces glucose reabsorption in the kidney, leading to increased urinary glucose excretion.
Indications
- Type 2 diabetes mellitus (as an adjunct to diet and exercise)
Dosage
Adults (≥18 years): Recommended dose: 100 mg once daily before the first meal of the day. May increase to 300 mg once daily in patients tolerating 100 mg/day with eGFR >60 mL/min/1.73 m² and requiring additional glycemic control.
Elderly (>75 years): Starting dose: 100 mg once daily.
Renal impairment:
eGFR >60 mL/min/1.73 m²: No dose adjustment required.
eGFR 45-<60 mL/min/1.73 m²: Do not exceed 100 mg/day.
eGFR <45 mL/min/1.73 m²: Do not initiate; discontinue if eGFR falls below 45 mL/min/1.73 m².
Hepatic impairment: Mild-moderate: No dose adjustment; severe: Caution required.
Note: Not for treatment of type 1 diabetes or diabetic ketoacidosis.
Side effects
Common side effects (≥5%): Female genital mycotic infections, urinary tract infection, increased urination, increased thirst, nausea, constipation.
Other: Hypotension (postural hypotension), hyperkalemia, hypoglycemia (with other antidiabetic agents), increased LDL cholesterol, toe amputation (rare).
Serious (rare): Diabetic ketoacidosis, acute kidney injury, Fournier's gangrene (life-threatening genital infection), anaphylaxis, angioedema.
Precautions & warnings
- Dehydration and hypotension: Increased urination may cause fluid loss; ensure adequate hydration. Caution in patients taking diuretics, NSAIDs, or renin-angiotensin system blockers for diabetes or dialysis.
- Genital fungal infections and UTIs: Practice good hygiene; inform your doctor if symptoms of infection occur.
- Hypoglycemia: Increased risk when used with insulin or sulfonylureas; monitor blood glucose regularly.
- Diabetic ketoacidosis (DKA): Risk of DKA before surgery, during acute illness, or significantly reduced food intake; monitor blood ketones.
- Renal impairment: Do not use if eGFR <45 mL/min/1.73 m²; monitor eGFR regularly.
- Toe amputation (rare): Caution in patients with peripheral vascular disease, neuropathy, or foot ulcers; perform regular foot examinations.