৳ 1,335/unit
Pack: ৳ 1,335
৳ 1,335/unit
Pack: ৳ 1,335
At a glance
Cisplatin is an anti-cancer medication used in the treatment of ovarian, cervical and testicular cancer.
Indications
- Metastatic Testicular Tumors
- Metastatic Ovarian Tumors
- Advanced Bladder Cancer
- Non-Small Cell Lung Carcinoma
- Cervical Cancer
Pharmacology
Cisplatin is a platinum compound of which only the cis-isomer is active. It appears to produce intra-and interstrand cross links which modify DNA structure and inhibit DNA synthesis. In addition and to a lesser extent Cisplatin inhibits protein and RNA synthesis. It does not appear to be phase-specific in the cell cycle.
Dosage
Metastatic Testicular Tumors: 20 mg/m²/day IV for 5 days/cycle (in combination with other chemotherapeutic agents).
Advanced Bladder Cancer: 50-70 mg/m² IV every 3-4 weeks.
Metastatic Ovarian Carcinoma: 75-100 mg/m² IV every 4 weeks (in combination with cyclophosphamide).
Non-Small Cell Lung Carcinoma: 75 mg/m² (in combination with Paclitaxel) every 3 weeks.
Renal Dose: CrCl 10-50 mL/min: Decrease dose 50%; CrCl <10 mL/min: Contraindicated.
Side effects
Common Side Effects:
- Injection site reactions (pain, swelling, redness)
- Increased risk of infection
- Ear disorders (hearing loss, tinnitus)
- Vomiting
- Nausea
- Decreased blood cells (red cells, white cells, and platelets)
- Renal impairment (kidney damage)
- Peripheral neuropathy (tingling and numbness of feet and hand)
- Electrolyte disturbances (hypomagnesemia, hypocalcemia, hypokalemia)
Serious Side Effects: Ototoxicity, nephrotoxicity, neurotoxicity, severe bone marrow suppression.
Use in pregnancy
[CONSULT YOUR DOCTOR] Cisplatin is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor. Pregnancy Category D.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- [UNSAFE] Cisplatin may cause side effects which could affect your ability to drive. Sleepiness and/or vomiting could affect your ability to drive.
- Renal function: Monitor creatinine, BUN, and electrolytes. Hydrate with 1-2 L fluid before treatment and ensure adequate hydration.
- Bone marrow function: Monitor complete blood counts frequently.
- Hearing function: Perform audiometry prior to therapy and repeat when symptoms occur.
- CNS functions: Neurologic examination warranted; discontinue if neurotoxic signs appear.
- Contraindicated during pregnancy and lactation.
Overdose effects
Acute overdosage may result in kidney failure, liver failure, deafness, ocular toxicity (including retinal detachment), significant myelosuppression, intractable nausea and vomiting and/or neuritis. Death can occur following overdosage. No proven antidotes have been established. Hemodialysis has little effect on removing platinum from the body.
Storage conditions
Store the vial in original carton at 25°C. Do not refrigerate. Protect from light and keep out of reach of children.