Coveram 4/104mg+10mg

Perindopril + Amlodipine is used to treat hypertension (high blood pressure). This is a combination of two medicines that controls blood pressure when a single medication is not effective. It helps to lower high blood pressure and thus reduces the chances of future heart attack and stroke. You can take Perindopril + Amlodipine at any time of day, on empty stomach, but it is best to take it at the same time each day. Keep taking it for as long as advised by your doctor. Even if you feel well, do not stop this medicine on your own because high blood pressure often has no symptoms. If you stop taking it, your condition may get worse. Keeping active with regular exercise, reducing your weight and eating a healthy diet will also help control your blood pressure. Follow your doctor's advice while taking this medicine. It may cause side effects like ankle swelling, headache, cough, weakness, and tiredness. It may also cause dizziness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. This might raise the level of potassium in the blood, hence avoid potassium rich food or supplements. You may be asked for regular monitoring of blood pressure, kidney function, and electrolytes level while on the treatment. Before taking it, let your doctor know if you have any liver or kidney problems. Pregnant or breastfeeding women should also consult their doctor for advice before taking this medicine. You also need to tell your doctor what other medicines you are taking especially those used to treat high blood pressure or heart conditions. Perindopril + Amlodipine is a combination of two medicines: Amlodipine and perindopril which lower blood pressure effectively. It works by relaxing blood vessels so that blood flows more smoothly and the heart can pump blood more efficiently.

• Hypertension (high blood pressure)

Perindopril, a prodrug of perindoprilat, is an ACE inhibitor which prevents convertion of angiotensin I to angiotensin II, thereby increasing plasma renin activity and decreasing vasoconstriction and aldosterone secretion. Amlodipine, a dihydropyridine Ca channel blocker, inhibits transmembrane influx of Ca ions into vascular smooth muscle and cardiac muscle thereby causing relaxation and vasodilation. It also directly acts on vascular smooth muscle causing reductions in peripheral vascular resistance and BP.

Adult Dose: Hypertension Indicated for the treatment of hypertension in patients whose blood pressure is not adequately controlled on monotherapy or as initial therapy in patients likely to need multiple drugs to achieve blood pressure goals Tablet 4 mg/5 mg PO qDay with or without food Adjust dose according to blood pressure goals; wait 7-14 days between titration steps Not to exceed 14 mg/10 mg qDay Hepatic impairment: There are no data to guide dosing recommendations Renal Dose: Renal Impairment CrCl <30 mL/min: Not recommended CrCl 30-80 mL/min (mild or moderate renal impairment): Do not exceed 7/5 mg

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Perindopril + Amlodipine is to be taken empty stomach.

Common: • Ankle swelling • Headache • Tiredness • Palpitations • Increased potassium level in blood • Sleepiness • Cough • Taste change • Flushing (sense of warmth in the face, ears, neck and trunk) • Decreased blood pressure • Upset stomach

[UNSAFE] Perindopril + Amlodipine may cause side effects which could affect your ability to drive. Perindopril + Amlodipine usually does not affect alertness but dizziness or weakness due to low blood pressure may occur in some patients. This may affect your driving ability. You have been prescribed Perindopril + Amlodipine for the treatment of high blood pressure. Lowering blood pressure reduces chance of future heart attack & strokes. It may cause dizziness. Get up slowly when rising from a sitting or lying position. Do not take Perindopril + Amlodipine if you are pregnant or planning for pregnancy.

History of idiopathic angioedema. Severe hypotension, shock (e.g. cardiogenic shock), left ventricular outflow tract obstruction (e.g. high grade aortic stenosis), heart failure after acute MI. Pregnancy and lactation. Concomitant use w/ aliskiren esp in patients w/ DM or renal impairment (GFR <30 mL/min/1.73 m2).

Increased hypotensive effects w/ antihypertensive agents (e.g. β-blockers), diuretics, and vasodilators. May increase serum levels and toxicity of lithium. May cause nitritoid reactions w/ Na aurothiomalate. Increased risk of angioneurotic oedema w/ estramustine. May increase hypoglycaemic effect w/ insulin or sulfonamides. Increased antihypertensive effect and risk of orthostatic hypotension w/ TCAs, antipsychotics, anaesthetics, α-blockers. May increase risk of angioedema w/ mammalian target of rapamycin (mTOR) inhibitors (e.g. sirolimus, everolimus, temsirolimus). May cause worsening of renal function and loss of antihypertensive effect w/ NSAIDs. Decreased antihypertensive effects w/ NSAIDs and sympathomimetics.

[UNSAFE] It is unsafe to consume alcohol with Perindopril + Amlodipine.

[CONSULT YOUR DOCTOR] Perindopril + Amlodipine is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[SAFE IF PRESCRIBED] Perindopril + Amlodipine is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CAUTION] Perindopril + Amlodipine should be used with caution in patients with kidney disease. Dose adjustment of Perindopril + Amlodipine may be needed. Please consult your doctor. Caution should be advised in patients with renal impairment. [CAUTION] Perindopril + Amlodipine should be used with caution in patients with liver disease. Dose adjustment of Perindopril + Amlodipine may be needed. Please consult your doctor. Inform your doctor if you develop any signs and symptoms of jaundice while taking this medicine.

please tell me medicine for bleeding piles.i take amtas for high blood pressure and ocid 20 for acidity. I have gas in stomach. weight 127. Hi For bleeding plies, you should consult a surgeon. Its very important for the piles to be examined first and then the treatment is suggested mostly Im suffering from high hair falling and baldness I want to go for hair trance plant. So any option to avoid this kindly suggest best way Medical treatment and prp therapy Facing serious hair loss problem Go for prp therapy PRP Best way for hairregrowth please explain me Check online for PRP . Hair growth is not just with PRP . Many medicines have to be combined together I have a hairloss problem , please help me . go for PRP therapy by I am having hair loss problem in this young age. Please advice me what to do. go for prp therapy by I m loosing may hairs. Hairs becoming dry and thin what should i do U should go for Prp therapy Hair lose problem from so many years now baldness appearing clearly. Pinfecia also I used and mintop Forte also. After I stopped that than problem re occurred. Help me pls Keraglo men and trichton. Keeraboost also used sir You can take prp therapy also