Daclavir60mg
Rx- Generic:
- Daclatasvir
- Company:
- Beacon Pharmaceuticals PLC
- Dosage form:
- Tablet
- Pack size:
- Tablet
৳ 400/unit
Pack: ৳ 400
At a glance
Daclatasvir — brands, prices, indication, dosage and side effects available in Bangladesh.
Description
Daclatasvir is an antiviral medication. It is used along with other medications for the treatment of chronic hepatitis C virus (HCV) infection. It works by lowering a load of hepatitis C virus in the body and removing the virus from the blood over a period of time. Daclatasvir should be taken in the dose and duration as advised by your doctor. It should be taken with or without food, preferably at a fixed time. Do not skip any doses and finish the full course of treatment even if you feel better If you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose. It has fewer side effects as compared to other similar medicines, like fatigue, headache, nausea, insomnia (difficulty sleeping) and anemia (low red blood cell count). Inform your doctor if these side effects persist for a longer duration. Please consult your doctor if you are pregnant, planning to conceive or breastfeeding. Daclatasvir is an antiviral medication. It works by lowering a load of hepatitis C virus in the body and removing the virus from the blood over a period of time.
Indications
• Chronic hepatitis C virus (HCV) infection
Mechanism of action
Inhibits NS5A, a nonstructural protein encoded by HCV. Binds to the N-terminus within domain 1 of NS5A, which may cause structural distortions that interfere with NS5A functions, and thereby inhibits both viral RNA replication and virion assembly.
Dosage
Adult Dose: Hepatitis C Indicated for use with sofosbuvir for chronic hepatitis C virus (HCV) genotypes 1 and 3 infection Genotype 1 Without cirrhosis or with compensated (Child-Pugh A) cirrhosis: 60 mg (plus sofosbuvir 400 mg) PO qDay for 12 weeks Decompensated (Child-Pugh B or C) cirrhosis or posttransplant: 60 mg (plus sofosbuvir 400 mg) PO qDay plus ribavirin for 12 weeks Genotype 3 Without cirrhosis: 60 mg (plus sofosbuvir 400 mg) PO qDay for 12 weeks Compensated (Child-Pugh A) or decompensated (Child-Pugh B or C) cirrhosis, or posttransplant: 60 mg (plus sofosbuvir 400 mg) PO qDay plus ribavirin for 12 weeks Hepatic impairment (any degree): No dose adjustment required Renal Dose: Renal impairment (any degree): No dose adjustment required
Administration
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Daclatasvir may be taken with or without food, but it is better to take it at a fixed time.
Side effects
Common: • Fatigue • Headache • Nausea • Insomnia (difficulty in sleeping) • Anemia (low number of red blood cells)
Precautions & warnings
[CONSULT YOUR DOCTOR] It is not known whether Daclatasvir alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Daclatasvir is used along with other medications for the treatment of chronic hepatitis C virus (HCV) infection. Do not skip any doses and finish the full course of treatment even if you feel better. It has fewer side effects compared to other similar medications. Take it with food, preferably at the same time everyday. You will usually need to take this medicine every day for either 12 or 24 weeks. It may cause fatigue, dizziness, and blurred vision. Don't drive or do anything requiring concentration until you know how it affects you. Your doctor may monitor your liver function and the amount of hepatitis C virus in your body regularly. Do not stop taking Daclatasvir without your doctor’s advice.
Contraindications
Hypersensitivity. Co-administration w/ strong CYP3A4 inducers & P-gp eg phenytoin, carbamazepine, oxcarbazepine, phenobarb, rifampicin, rifabutin, rifapentine, systemic dexamethasone, St. John's wort.
Drug interactions
May lead to lower exposure & loss of efficacy w/ phenytoin, carbamazepine, oxcarbazepine, phenobarb, rifampicin, rifabutin, rifapentine, systemic dexamethasone & St. John's wort. Decreased plasma levels & therapeutic effect w/ strong or moderate CYP3A4 & P-gp inducers. Increased plasma levels w/ strong CYP3A4 inhibitors. May increase systemic exposure of P-gp, OATP, 1B1, OCT1 or BCRP substrates. Boceprevir, telaprevir, atazanavir/ritonavir, efavirenz, cobicistat-containing, clarithromycin, telithromycin, erythromycin, dabigatran, etexilate, posaconazole, voriconazole, amiodarone, digoxin, Ca channel blockers, HMG-CoA reductase inhibitors.
Food interactions
[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Daclatasvir. Please consult your doctor.
Use in pregnancy
[CONSULT YOUR DOCTOR] Daclatasvir may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Use in lactation
[SAFE IF PRESCRIBED] Daclatasvir is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Renal / hepatic impairment
[SAFE IF PRESCRIBED] Daclatasvir is safe to use in patients with kidney disease. No dose adjustment of Daclatasvir is recommended. [SAFE IF PRESCRIBED] Daclatasvir is safe to use in patients with liver disease. No dose adjustment of Daclatasvir is recommended.
Common questions
How to treatment of HEPATITIS C VIRUS https://www.1mg.com/otc/himalaya-liv.-52-ds-tablet-otc135545One ?one tablet morning & evening after taking food , use at least 1-2 monthsUse this medicine along with your treatment I am affected from hepatitis c virus diagnosed with confirmed genotype. Meanwhile i am pregnant will hepatitis virus pass on my baby. Or i should abort Your reports are of february with no ongoin liver damage. You havnt got the quantitative analysis. Most probably you wont need to abort. But be in constant follow up of good gastroenterologist near you. How to get rid of Hepatitis C virus present inside the body which is still nonreactive ? Consult a Gastro enterologist Have chronic infection with semun c/s Ecoli Please elaborate your symptoms, history, treatment and investigations done. What is the GTT, HCB, tests in pregnancy ? These tests help to know chicness of diabetes in a pregnant mother and HCV is a hepatitis test. Suffering from Hepatitis B virus from last one week. Please suggest me. Pls consult a gastroenterologist Hepatitis c , drug suggest me salt name , popular brand in india Hello doctor , will you suggest me drug for hepatitis c you need to be examined in clinic before any opinion can be given Had mild chikangunya viral infection. Fever is gone but the joint pain is there since 2 weeks. How can I cure it completely? Pain is in shoulder, knees, wrist and right above hip area U can take tab etoshine 60mg twice daily for 5days