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At a glance

Triptorelin Acetate is used in the treatment of prostate cancer. It is also used to treat endometriosis and central precocious puberty.

Indications
  • Prostate cancer
  • Endometriosis
  • Precocious puberty
  • Uterine fibroids
  • Female infertility
Pharmacology

Triptorelin is a synthetic analogue of natural gonadotropin-releasing hormone. Initial administration stimulates the release of pituitary gonadotrophins with a transient increase in testosterone levels in men and oestradiol levels in women, leading to an initial worsening of symptoms during the first week. Prolonged administration leads to suppression of gonadotrophins and a decrease in plasma testosterone or oestradiol after approximately 20 days.

Dosage

Adult Dose (Parenteral):

  • Prostate cancer: 22.5 mg IM every 6 months, or 11.25 mg IM every 3 months, or 3.75 mg IM every month
  • Endometriosis/Uterine fibroids: 3 or 3.75 mg IM every 4 weeks for up to 6 months; begin during the first 5 days of the menstrual cycle
  • Female infertility: 0.1 mg daily SC, in conjunction with gonadotrophins, starting from the 2nd day of the menstrual cycle for 10-12 days

Child Dose: 30 kg: 3.75 mg IM or SC; first 3 doses at 14-day intervals, then every 4 weeks

Side effects

Common Side Effects:

  • Weakness
  • Increased sweating
  • Back pain
  • Paresthesia
  • Decreased libido
  • Impotence
  • Hot flashes
  • Fatigue
Use in pregnancy

Use in Pregnancy: Highly unsafe; studies show significant harmful effects to the developing baby; consult your doctor.

Pregnancy Category: X — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • May affect ability to drive
  • May cause dizziness, tiredness or blurred vision
  • Menstrual periods will stop; resume 7-12 weeks after final injection
  • Consult doctor if menstrual bleeding continues during treatment
  • Use non-hormonal contraception to prevent pregnancy
  • Long-term treatment may lead to bone loss and higher risk of fractures
  • Take vitamin D and calcium supplements
Overdose effects

Symptoms: Hot flashes, dizziness, electrolyte imbalance.

Treatment: Supportive care.

Storage conditions

Store at 15-30°C, away from light; keep out of reach of children.

Triptorelin Acetate — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.