Desirox Dis500mg

Deferasirox is a medicine used in the treatment of chronic iron overload caused by frequent blood transfusion. It helps remove the excess iron from the body and reduce the risk of it causing organ damage. Deferasirox should be taken in empty stomach. Take it regularly at a fixed time each day to get the maximum benefit of the medicine. Using of Deferasirox may cause common side effects such as nausea, headache, constipation, diarrhea and increased liver enzyme. If the side effects persist or worsen, inform your doctor. Deferasirox traps and removes excess iron which is then excreted mainly in the stools. This reduces the risk of organ damage.

• Iron overload • Transfusion dependent thalassemia

Deferasirox is an orally active chelator that is selective for iron (as Fe3+ ion). It is a tridentate ligand that binds iron with high affinity in a 2:1 ratio. It is used in the management of chronic iron overload.

Adult Dose: Transfusional Hemosiderosis Indicated for treatment of chronic iron overload caused by blood transfusion 20 mg/kg PO qDay; may increase by 5-10 mg increments based on serum ferritin; if not controlled on 30 mg/kg/day (ie, serum ferritin persistently >2500 mcg/L), may increase up to 40 mg/kg qDay Nontransfusion-Dependent Thalassemia Indicated for treatment of chronic iron overload caused by nontransfusion-dependent thalassemia syndromes and with a liver iron (Fe) concentration (LIC) of at least 5 mg Fe per gram of dry weight (dw) and a serum ferritin >300 mcg/L 10 mg/kg PO qDay (calculate dose to nearest tablet size); if LIC >15 mg Fe/g dw after 4 weeks, consider increasing dose to 20 mg/kg/day Hepatic Impairment Mild (Child-Pugh A): No dose adjustment required Moderate (Child-Pugh B): Decrease initial dose by 50% Severe (Child-Pugh C): Avoid use Child Dose: Transfusional Hemosiderosis Indicated for treatment of chronic iron overload caused by blood transfusion 2500 mcg/L), may increase up to 40 mg/kg qDay Nontransfusion-Dependent Thalassemia Indicated for treatment of chronic iron overload caused by nontransfusion-dependent thalassemia syndromes and with a liver iron (Fe) concentration (LIC) of at least 5 mg Fe per gram of dry weight (dw) and a serum ferritin >300 mcg/L 15 mg Fe/g dw after 4 weeks, consider increasing dose to 20 mg/kg/day Renal Dose: Renal Impairment Baseline renal impairment CrCl 40-60 mL/min: Reduce starting dose by 50% Serum Cr >2 xULN or CrCl <40 mL/min: Do not use

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Deferasirox is to be taken empty stomach.

If you miss a dose of Deferasirox, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.

Common: • Nausea • Headache • Vomiting • Rash • Abdominal pain • Constipation • Itching • Increased liver enzymes • Abdominal distension • Diarrhea

[UNSAFE] Deferasirox may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Always take deferasirox tablet on an empty stomach by dissolving into a glass of water. Do not chew, crush, break or swallow the tablets as a whole. Deferasirox may cause dizziness. It is advisable not to drive or operate any machinery until you feel normal again. Avoid taking deferasirox if you are pregnant, planning to become pregnant or are breast feeding.

Hypersensitivity.

Not to be used with aluminium-containing antacids as it may chelate aluminium.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Deferasirox. Please consult your doctor.

[CONSULT YOUR DOCTOR] Deferasirox may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Deferasirox is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[UNSAFE] Deferasirox is probably unsafe to use in patients with kidney disease and should be avoided. Please consult your doctor. [CAUTION] Deferasirox should be used with caution in patients with liver disease. Dose adjustment of Deferasirox may be needed. Please consult your doctor. Limited information is available on the use of Deferasirox in these patients.

Hello doctor I have thallassemia major since birth and due to iron overload of repetitive blood transfusion i have diagnosed with diabetes 3 yr ago -at the time of diabetes diagnosis my sugar level is 650 mg/dl. Now according to my case what could be the state of my diabetes type 1 or type 2 ? Hello, Diabetes in thalassaemia is thought to be caused mainly by iron overload, from repeated blood transfusions, damaging the pancreas. Insulin secretion may be reduced, possibly because iron is directly toxic to the insulin producing pancreatic ?-cells. So it is type 1 DM . Diabatic for last 4 years insulin dependent D Vitamin iron deficiency Dear Sir Thank you for sharing your reports with me. It shows the following important things: 1. your iron level is low, for this you can have a diet rich in lots of iron like jaggery, spinach, leafy vegetables etc. Your vitamin D level is low, for this you can have calcirol sachet in milk once a week for at least 6 weeks. Your glycosylated hemoglobin and average blood glucose level is high, you should consult your doctor for this for the review of treatment. Diabatic for last 5 years insulin dependent D Vitamin iron deficiency Hi you need to consult doctor nearby by.Or u can visit our clinic at sector 52 gurgaon in RDCITY snergy clinic. Diabetic pt should be in regular contact with the diabetologist or treating doctor. Do all regular tests and follow diet and exercise. Disease can be well controlled. A person can avoid diabetic complications. Diabatic for last 4 years insulin dependent D Vitamin n iron deficiency Take D suppliments and follow ur doctor advise What test do I ask for testing my iron content in blood plus what test will show if my daughter is thalassemia minor? CBC, Iron Studies and Abnormal Haemoglobin Studies Hi Doctor, I am 30 yrs old. I am using calcimax 500. Its ok for me. But I want tablet of iron rich, blood increasing tablet after pregnancy. I have 6 month old baby. Thanks in advance. You can take cap Autrin for iron. Calcimax is fine. You can continue with the same H.B is just 7 gram not improving iron not suitable Please consult Dr. will take detail history and will examine your child in detail. may ask you for blood test. All information will be used to determine exact underlying cause of problem. Depending upon cause will prescribe you treatment.Just to give you idea i am giving examples of diseases where anemia is presentCongenital dyserythropoietic anemia Diamond-Blackfan anemia G-6-PD deficiency Hemophagocytic lymphohistiocytosis (HLH), congenital or acquired Iron refractory iron deficiency anemia (IRIDA) Nutritional iron deficiency Paroxysmal nocturnal hemoglobinuria Pure red cell aplasia Rheumatoid arthritis Sideroblastic anemia Unstable hemoglobinopathies Hookworm infection Hypothyroidism Myelodysplastic syndrome Myelofibrosis Systemic lupus erythematosus Thalassemia Thalassemia intermedia Pyruvate kinase deficiency i am patient of Venous infarct with convulsion disorder. i was advised to take levetricetam 500 mg tab for 2 years, is it really required to take 2 yeras of such drug. what are the side effects after 2 years as per experience. its better to take to avoid fits; side effectsa re dose dependent