৳ 900/unit
Pack: ৳ 900
৳ 900/unit
Pack: ৳ 900
At a glance
Adapalene + Clindamycin Phosphate is a topical gel used for the treatment of acne vulgaris. Adapalene is a retinoid that normalizes skin cell turnover and unclogs pores, while Clindamycin is an antibiotic that destroys acne-causing bacteria. This dual action reduces inflammation and prevents new breakouts. It is usually applied once daily at night to clean, dry skin. In Bangladesh, it is available under brand names like Deriva CMS, Clin Bold Gel, etc.
Indications
Used for the treatment of acne vulgaris
Pharmacology
Adapalene is a retinoid that normalizes skin cell turnover and prevents comedone formation. Clindamycin Phosphate is an antibiotic that kills acne-causing bacteria (Propionibacterium acnes) by inhibiting bacterial protein synthesis .
Dosage
Adults and children over 12 years: Apply a thin layer to clean, dry skin once daily at night . During the first week of treatment, acne may worsen (initial exacerbation), which is normal. Therapeutic effect is observed 8-12 weeks after starting treatment
Side effects
Common Side Effects: • Redness (Erythema) • Peeling • Dryness • Itching (Pruritus) • Burning or stinging sensation • Application site irritation Serious Side Effects (Rare – Consult Doctor): • Allergic reactions (Anaphylaxis, Angioedema, Urticaria) • Diarrhea • Bloody diarrhea • Colitis (including pseudomembranous colitis) • Severe skin irritation or contact dermatitis
Use in pregnancy
Available data with this combination in pregnant women are insufficient. Clindamycin has not been associated with major birth defects. Adapalene animal studies at high oral doses showed fetal malformations . Use during pregnancy only if clearly needed and with medical advice.
Precautions & warnings
Avoid contact with eyes, lips, areas of the nose, and mucous membranes . Do not apply to eczematous skin lesions, sunburns, cuts, or other skin lesions . Avoid excessive sunlight and UV light (tanning beds, sun lamps) during treatment due to increased skin sensitivity . Contraindicated in patients with a history of regional enteritis, ulcerative colitis, or antibiotic-associated colitis . Discontinue use if significant diarrhea occurs . Consult your doctor during pregnancy and breastfeeding.
Overdose effects
Possible redness and peeling of the skin when excessive amounts of gel are applied. Therapy is symptomati
Storage conditions
Store below 30°C, protected from light. Keep out of reach of children. Do not use after the expiry date.