osudhkosh
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Company•Ziska Pharmaceuticals Ltd.

Eluxan 75

Rx
Generic: Eluxadoline

৳ 125/unit

Pack: ৳ 1,250

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At a glance

Eluxadoline is a medicine used for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D) in adult men and women. It is a mu-opioid receptor agonist that reduces intestinal peristalsis and desensitizes intestinal nerves.

Indications
  • Diarrhea-predominant irritable bowel syndrome (IBS-D) in adult men and women
Pharmacology

Eluxadoline is a mu-opioid receptor agonist, kappa opioid receptor agonist and delta opioid receptor antagonist. It works directly in the intestine to reduce peristalsis and makes the nerves in the intestine less sensitive to stimulation.

Dosage

Adult Dose: 100 mg PO BID with food. (Mild-moderate hepatic impairment: 75 mg PO BID).

Discontinue in patients who develop severe constipation lasting >4 days.

Hepatic Dose: Mild-moderate (Child-Pugh A or B): 75 mg BID; Severe (Child-Pugh C): Contraindicated.

Side effects

Common Side Effects (1-10%):

  • Constipation (7-8%)
  • Nausea (7-8%)
  • Abdominal pain (6-7%)
  • URT infection (3-5%)
  • Vomiting (4%)
  • Nasopharyngitis (3-4%)
  • Abdominal distention (3%)
  • Bronchitis (3%)
  • Dizziness (3%)
  • Flatulence (3%)
  • Rash (3%)
  • Increased ALT (2-3%)
  • Fatigue (2-3%)
  • Viral gastroenteritis (1-3%)

Serious (<1%): Severe constipation

Use in pregnancy

No studies in pregnant women. Animal reproduction studies showed no teratogenic effects. Use only if needed.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Eluxadoline is a mu opioid receptor agonist; risk of sphincter of Oddi spasm leading to pancreatitis or hepatic enzyme elevation.
  • Caution in patients without gallbladder.
  • Evaluate alcohol intake prior to starting therapy; instruct patients to avoid chronic or acute excessive alcohol use.
  • Monitor for new or worsening abdominal pain that may radiate to back or shoulder.
  • Instruct patients to stop therapy and seek medical attention if symptoms of pancreatitis occur.
Overdose effects

Limited data on overdose. Do not exceed indicated dosing. Provide symptomatic treatment.

Storage conditions

Store in a cool & dry place, protect from light. Keep out of reach of children.

Eluxadoline — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.