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At a glance

Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) used for moderate to severe pain in conditions such as osteoarthritis and rheumatoid arthritis. It helps relieve pain and swelling in joints and muscles.

Indications
  • Osteoarthritis
  • Rheumatoid arthritis
  • Acute gout
  • Acute musculoskeletal conditions
  • Post-operative pain
  • Juvenile idiopathic arthritis
Pharmacology

Piroxicam is an NSAID that inhibits COX-1 and COX-2 enzymes to prevent prostaglandin synthesis. It reduces fever by acting on the hypothalamic heat-regulating center, inhibits thromboxane A2 to reduce platelet aggregation, and decreases pain receptor sensitivity. It also exerts anti-inflammatory effects through lysosomal stabilization and reduced kinin and leukotriene production.

Dosage

Adult Dose (Oral):

  • Rheumatic disorders: Initial 20 mg/day; Maintenance 10-30 mg (single or divided doses)
  • Acute gout: 40 mg/day (5-7 days)
  • Acute musculoskeletal/Post-op pain: 40 mg/day (2 days); Maintenance 20 mg/day (1-2 weeks)

Pediatric Dose:

  • Juvenile idiopathic arthritis (>6 years, 46 kg): 20 mg once daily
Side effects

Common Side Effects:

  • Vomiting
  • Stomach pain
  • Nausea
  • Indigestion
  • Diarrhea
  • Headache
  • Dizziness
Use in pregnancy

Use in Pregnancy: Unsafe during pregnancy; definite evidence of risk to the developing baby; doctor may prescribe in life-threatening situations if benefits outweigh risks.

Pregnancy Category: D — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • May decrease alertness; do not drive if drowsy or dizzy
  • Caution in history of stomach ulcers, GI bleeding
  • Caution in heart disease, high blood pressure, liver or kidney disease
  • Avoid alcohol
  • Avoid concomitant use with anticoagulants, aspirin, other NSAIDs
Overdose effects

Overdose: Nausea, vomiting, abdominal pain, dizziness, drowsiness, convulsions, kidney and liver damage; treatment: symptomatic and supportive; activated charcoal; gastric lavage.

Storage conditions

Store in a cool and dry place, away from light; keep out of reach of children.

Piroxicam — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.