৳ 14.72/unit
Pack: ৳ 14.72
৳ 14.72/unit
Pack: ৳ 14.72
At a glance
Piroxicam is a non-steroidal anti-inflammatory drug (NSAID) used for moderate to severe pain in conditions such as osteoarthritis and rheumatoid arthritis. It helps relieve pain and swelling in joints and muscles.
Indications
- Osteoarthritis
- Rheumatoid arthritis
- Acute gout
- Acute musculoskeletal conditions
- Post-operative pain
- Juvenile idiopathic arthritis
Pharmacology
Piroxicam is an NSAID that inhibits COX-1 and COX-2 enzymes to prevent prostaglandin synthesis. It reduces fever by acting on the hypothalamic heat-regulating center, inhibits thromboxane A2 to reduce platelet aggregation, and decreases pain receptor sensitivity. It also exerts anti-inflammatory effects through lysosomal stabilization and reduced kinin and leukotriene production.
Dosage
Adult Dose (Oral):
- Rheumatic disorders: Initial 20 mg/day; Maintenance 10-30 mg (single or divided doses)
- Acute gout: 40 mg/day (5-7 days)
- Acute musculoskeletal/Post-op pain: 40 mg/day (2 days); Maintenance 20 mg/day (1-2 weeks)
Pediatric Dose:
- Juvenile idiopathic arthritis (>6 years, 46 kg): 20 mg once daily
Side effects
Common Side Effects:
- Vomiting
- Stomach pain
- Nausea
- Indigestion
- Diarrhea
- Headache
- Dizziness
Use in pregnancy
Use in Pregnancy: Unsafe during pregnancy; definite evidence of risk to the developing baby; doctor may prescribe in life-threatening situations if benefits outweigh risks.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May decrease alertness; do not drive if drowsy or dizzy
- Caution in history of stomach ulcers, GI bleeding
- Caution in heart disease, high blood pressure, liver or kidney disease
- Avoid alcohol
- Avoid concomitant use with anticoagulants, aspirin, other NSAIDs
Overdose effects
Overdose: Nausea, vomiting, abdominal pain, dizziness, drowsiness, convulsions, kidney and liver damage; treatment: symptomatic and supportive; activated charcoal; gastric lavage.
Storage conditions
Store in a cool and dry place, away from light; keep out of reach of children.