৳ 728/unit
Pack: ৳ 728
৳ 728/unit
Pack: ৳ 728
At a glance
Propofol is a highly lipid soluble, short-acting intravenous general anesthetic used for induction and maintenance of general anesthesia, sedation during intensive care, and sedation for surgical and diagnostic procedures.
Indications
- Induction and maintenance of general anesthesia
- Sedation during intensive care
- Sedation for surgical and diagnostic procedures
Pharmacology
Propofol is a highly lipid soluble, short-acting IV general anesthetic. It works through positive modulation of GABA's inhibitory function via GABA-A receptors. Onset of general anesthesia occurs within 15-45 seconds. Most patients recover rapidly without confusion or nausea.
Dosage
Adult Dose (IV):
- General anesthesia induction: 40 mg every 10 seconds; usual dose 1.5-2.5 mg/kg
- Maintenance: 4-12 mg/kg/hr OR intermittent bolus 20-50 mg
- Elderly/neurosurgical: 20 mg every 10 seconds; maintenance 3-6 mg/kg/hr; dose 1-1.5 mg/kg
- Sedation (diagnostic/surgical): 6-9 mg/kg/hr for 3-5 min OR 0.5-1 mg/kg slow IV over 1-5 min; maintenance 1.5-4.5 mg/kg/hr
- Ventilated patients: 0.3-4 mg/kg/hr
Pediatric Dose (IV):
- Anesthesia induction (3-16 years): 2.5-3.5 mg/kg over 20-30 sec
- Maintenance (2 months-16 years): 0.125-0.3 mg/kg/min
- Under 3 years: Not recommended
Side effects
Side Effects:
- Injection site pain
- Hypotension
- Transient apnea
- Headache
- Nausea
- Vomiting
- Bradycardia
- Seizures (rare)
- Hypersensitivity reactions
- Green or reddish-brown urine discoloration (with prolonged administration)
Use in pregnancy
Use in Pregnancy: Generally considered safe; animal studies show low or no adverse effects; limited human studies; do not use in obstetrics.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Should only be given by specialists in anesthesiology or under their supervision
- Resuscitation facilities must be available
- Caution in cardiac, respiratory, renal, or hepatic insufficiency
- Caution in hypovolemic patients
- May cause convulsions in epileptic patients
- Do not drive or operate machinery after administration
Overdose effects
Overdose may cause cardiorespiratory depression; treatment: artificial ventilation with oxygen, head lowering, leg elevation, pressor agents, plasma expanders if needed.
Storage conditions
Store at a temperature not exceeding 25°C; do not freeze; discard any unused solution.