৳ 30/unit
Pack: ৳ 300
৳ 30/unit
Pack: ৳ 300
At a glance
Dapagliflozin propanediol is an SGLT2 inhibitor used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Indications
- Type 2 diabetes mellitus
Pharmacology
Dapagliflozin is an inhibitor of Sodium-glucose co-transporter 2 (SGLT2). SGLT2, expressed in the proximal renal tubules, is responsible for the majority of the reabsorption of filtered glucose from the tubular lumen. By inhibiting SGLT2, Dapagliflozin reduces reabsorption of filtered glucose and lowers the renal threshold for glucose (RTG), and thereby increases urinary glucose excretion.
Dosage
Adult: Initial dose: 5 mg once daily in the morning, with or without food. May be increased to 10 mg once daily if needed (in patients with eGFR ≥60 mL/min/1.73 m²).
Side effects
Common Side Effects:
- Hypotension
- Ketoacidosis
- Acute kidney injury and renal function impairment
- Genital mycotic infections
- Urinary tract infection
- Nasopharyngitis
- Hypoglycemia
- Increased LDL-cholesterol
Use in pregnancy
Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Before initiating Dapagliflozin, assess volume status and correct hypovolemia in elderly, patients with renal impairment or low systolic blood pressure, and patients on diuretics.
- Monitor renal function during therapy.
- Risk of hypoglycemia with insulin or insulin secretagogues.
- Do not use in active bladder cancer; use with caution in patients with prior history of bladder cancer.
- Monitor blood sugar levels regularly.
Overdose effects
Overdose may lead to hypoglycemia, dehydration, and electrolyte imbalance. Seek medical attention.
Storage conditions
Store in a cool (below 30°C) & dry place protected from light. Keep away from reach of children.