Graftcept500mg

Mycophenolate Mofetil belongs to a group of medicines called immunosuppressants. It is used with other medicines to prevent your body from rejecting an organ (such as a kidney, heart or liver) after a transplant. It works by supressing your body’s immune system, so that it does not attack the new organ. The amount of Mycophenolate Mofetil you take and how often you take it depends on the type of transplant you have. Follow your doctor's instructions on this. You should take it on an empty stomach, at least 1 hour before or 2 hours after a meal. Swallow it as a whole, do not crush, chew or break it. Take the medicine regularly to get the maximum benefit and keep taking it even if you feel well. If you stop taking it, you may increase the chances of rejecting your transplanted organ. The treatment will continue for as long as you need it to prevent rejection. The most common side effects are nausea, vomiting, diarrhea, stomach pain, headache, high blood pressure and changes in the number of white blood cells. You may catch more infection than usual as medicine suppresses the immune system. There is also an increased risk of developing some cancers for this reason. To reduce your risk of skin cancer, limit your exposure to the sun and use sunscreen. There is a long list of potential side effects with this medicine. You should ask your doctor about them and what signs to look out for because some of them can be serious and need urgent medical attention. Mycophenolate Mofetil can cause birth defects and abortion so do not take it if you are pregnant, planning to become pregnant or breastfeeding. You should talk to your doctor before taking this medicine if you have any signs of infection or if you have any unexpected bruising or bleeding. You should also let your healthcare team know all other medicines you are taking as they may affect, or be affected by, this medicine. You will have regular tests to check for any changes in the number of your blood cells and the amount of sugar and cholesterol in your blood. Mycophenolate Mofetil is an immunosuppressant. It reduces the action of body's own defence system (the immune system) and prevents rejection of the transplanted organ.

• Prevention of organ rejection in transplant patients

Mycophenolic acid acts by blocking purine synthesis of human lymphocytes through reversible inhibition of inosine monophosphate dehydrogenase. It also inhibits proliferation of both T- and B- lymphocytes.

Adult Dose: Oral Adult Prophylaxis of acute renal graft rejection As Mycophenolate Mofetil (MMF): 1 g twice daily starting w/in 72 hr of transplantation. Max: 2 g/day. Prophylaxis of cardiac graft rejection, Liver Transplant Adult: As Mycophenolate Mofetil (MMF):1.5 g bid starting within 5 days after transplantation. Child Dose: 3 months Prophylaxis of organ rejection in patients receiving allogeneic renal transplants As Mycophenolate Mofetil (MMF): MMF (suspension): 600 mg/m² PO q12hr; not to exceed 2 g/day MMF: BSA 1.25-1.5 m²: 750 mg capsule PO q12hr MMF: BSA >1.5 m²: 1 g capsule/tablet PO q12hr Renal Dose: Renal impairment MMF: In severe renal impairment (glomerular filtration rate [GFR] <25 mL/min/1.73 m²), not to exceed 1 g q12hr No dosage adjustment needed in renal transplant patients experiencing delayed graft function post-operatively.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Mycophenolate Mofetil may be taken with or without food, but it is better to take it at a fixed time.

Common: • Nausea • Vomiting • Diarrhea • Abdominal pain • Headache • High blood pressure • Decreased white blood cell count (neutrophils)

[SAFE] Mycophenolate Mofetil does not usually affect your ability to drive. Your doctor has prescribed Mycophenolate Mofetil to stop your body from rejecting a transplanted organ (e.g. kidney, heart or liver). It may take 6 to 12 weeks for Mycophenolate Mofetil to start working. Keep taking it as prescribed. It may cause birth defects so birth control is required in females with reproductive potential. It makes you more susceptible to getting infections. Avoid contact with people who have an infection. Consult your doctor immediately if you develop a sore throat, high temperature, any other signs of infections. Protect yourself from direct sunlight by wearing protective clothing and applying a sunscreen with a high sun protection factor (SPF). Take it with food to minimize possible side effects like nausea and stomach pain. Your doctor may get regular blood tests done to monitor the levels of blood cells in your blood. Inform your doctor if you experience symptoms such as unexplained bruising or bleeding, sore throat, mouth ulcers, or fever.

Pregnancy, lactation. Rare hereditary deficiency of hypoxanthine-guanine phosphoribosyltransferase (HGPRT), including Kelley-Seegmiller or Lesch-Nyhan syndrome.

Increased plasma levels of both drugs when combined with aciclovir, valaciclovir, ganciclovir and valganciclovir. Reduced absorption with colestyramine, magnesium- and aluminium hydroxide-containing products, sevelamer and other calcium-free phosphate binders. Reduced plasma levels with ciclosporin, metronidazole, quinolones, rifamycins. May reduce plasma levels of progestins; may reduce efficacy of oral contraceptives. Increased plasma levels with probenecid. May reduce efficacy of live vaccines.

[SAFE] Consuming alcohol with Mycophenolate Mofetil does not cause any harmful side effects.

[CONSULT YOUR DOCTOR] Mycophenolate Mofetil is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[UNSAFE] Mycophenolate Mofetil is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

[SAFE IF PRESCRIBED] Mycophenolate Mofetil is probably safe to use in patients with kidney disease. Limited data available suggests that dose adjustment of Mycophenolate Mofetil may not be needed in these patients. Please consult your doctor. [CONSULT YOUR DOCTOR] There is limited information available on the use of Mycophenolate Mofetil in patients with liver disease. Please consult your doctor.

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