Imovane 7.5

Zopiclone is a prescription medicine used for short term treatment of insomnia. It reduces sleep onset time and frequent awakening at night. This medicine improves sleep maintenance and therefore ensures sound sleep. Zopiclone is never used for long term treatment of insomnia, because of its high habit forming potential. It should be taken on an empty stomach, preferably just before going to bed. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Take this medicine in the dose and duration as advised by your doctor as it is habit forming. Do not stop taking it suddenly without talking to your doctor as it may worsen your symptoms. Some common side effects of this medicine include metallic taste, drowsiness, sleepiness, and dry mouth. However, these are temporary and resolve on their own after some time. Please consult your doctor if these bother you or do not away. Zopiclone also causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you and do not take alcohol with it as it may worsen the dizziness. Inform your doctor if you develop any unusual changes in mood or behavior, new or worsening depression, hallucinations or suicidal thoughts while taking this medicine. Before taking Zopiclone, inform your doctor about all other medicines that you are taking, so that your doctor can advise if taking this medicine is right for you. Consult your doctor before taking this medicine if you are suffering from any liver or kidney problems. You should avoid smoking and alcohol while using this medicine. Pregnant and breastfeeding mothers should not use this medicine. However, if the need arises, please consult your doctor before using it. Zopiclone is a nonbenzodiazepine hypnotic. It has hypnotic and anxiolytic properties. It works by regulating the GABA receptor, thus relaxes the nerves and brain. This is how it helps you to fall asleep.

Difficulty falling asleep Frequent nocturnal awakenings Early morning awakening Short-term management of insomnia

Miscellaneous Sedatives & Hypnotics

Cyclopyrrolone Derivative (Short-acting Hypnotic Agent)

Zopiclone acts on the GABA-A receptor complex in the central nervous system and enhances chloride ion channel opening, resulting in reduced neuronal activity and hypnotic effects.

Zopiclone is a cyclopyrrolone derivative with hypnotic and sedative actions, anticonvulsant and muscle relaxant properties similar to benzodiazepines. It binds to a site in the GABA-A-benzodiazepine-chloride channel macromolecular-receptor complex which is different from that of the benzodiazepine binding site.

Adult Dose: Oral Short-term management of insomnia Adult: 7.5 mg at bedtime. Elderly: Initially, 3.75 mg at bedtime. Hepatic impairment: Mild to moderate: Initially 3.75 mg at bedtime. Severe: Contraindicated. Child Dose: Child: Not recommended. Renal Dose: Renal impairment: Initiate at 3.75 mg at bedtime.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Zopiclone is to be taken empty stomach.

If you miss a dose of Zopiclone, skip it and continue with your normal schedule. Do not double the dose.

Common side effects include: Somnolence Dizziness Confusion Memory impairment Feeling of drunkenness Nightmares Anxiety or nervousness Headache Tremor Muscle weakness Dry mouth Bitter taste Nausea Constipation or diarrhoea

[UNSAFE] Zopiclone may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Your doctor has prescribed Zopiclone to help you fall asleep faster and sleep for longer. It is best taken without food as a high-fat meal can reduce its absorption and effect. Take it 30 to 45 minutes before bedtime and only when you have time to sleep for at least 7 hours. It makes you feel dizzy next morning. Don't drive or do anything requiring concentration until you know how it affects you. It does not affect total sleep time. However, it reduces sleep onset time and frequent awakening at night. Never share your medication with any other person who also has a sleep problem. It may cause a bitter taste in your mouth or a dry mouth. Try sipping water and inform your doctor if it bothers you. Inform your doctor if your sleep doesn’t improve after 7 to 10 days of treatment. Stop taking medication and inform your doctor If you experience sleep driving or memory loss. Do not stop taking medication suddenly as it may lead to anxiety, mood changes, and restlessness.

Myasthenia gravis; respiratory failure; severe sleep apnoea syndrome; severe hepatic impairment; pregnancy, lactation.

Reduced hypnotic effect with phenytoin and carbamazepine. Increased drowsiness and incoordination with TCAs. Increased CNS depressant effect with alcohol and other CNS depressants. Decreased zopiclone concentration with rifampicin. Possible increase in zopiclone concentration with CYP3A4 inhibitors e.g. erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir.

Avoid alcohol as it may increase sedation and respiratory depression.

[CONSULT YOUR DOCTOR] Zopiclone is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[CONSULT YOUR DOCTOR] Zopiclone is probably unsafe to use during breastfeeding. Limited human data suggests that the drug may pass into the breastmilk and harm the baby.

Zopiclone is not indicated for patients under 18 years of age.

Elderly patients may require lower doses due to increased sensitivity and risk of falls.

[CAUTION] Zopiclone should be used with caution in patients with kidney disease. Dose adjustment of Zopiclone may be needed. Please consult your doctor. [CAUTION] Zopiclone should be used with caution in patients with liver disease. Dose adjustment of Zopiclone may be needed. Please consult your doctor. Use of Zopiclone is not recommended in patients with severe liver disease.

Overdose may cause: Severe drowsiness Confusion Coma Respiratory depression Hypotension

Store at room temperature (15°C–30°C). Protect from light. Keep out of reach of children.

Generic Name: Zopiclone Chemical Class: Cyclopyrrolone derivative Molecular Formula: C₁₇H₁₇ClN₆O₃ Molecular Weight: 388.81 g/mol

Question: What is Zopiclone? Answer: Zopiclone is a short-acting hypnotic medicine used for the treatment of insomnia. Question: What is Zopiclone used for? Answer: It is used for the short-term treatment of insomnia, including difficulty falling asleep, frequent nighttime awakenings, and early morning awakening. Question: How should Zopiclone be taken? Answer: Zopiclone should usually be taken before bedtime as directed by a healthcare professional. Do not take more than the prescribed dose. Question: What are the common side effects of Zopiclone? Answer: Common side effects include drowsiness, dizziness, confusion, memory impairment, dry mouth, bitter taste, headache, and gastrointestinal discomfort. Question: Can alcohol be taken with Zopiclone? Answer: No. Alcohol may increase the sedative effects of Zopiclone and increase the risk of breathing problems and other serious side effects. Question: How long can Zopiclone be used? Answer: Zopiclone is generally recommended for short-term use. Long-term use may increase the risk of dependence. Question: Can Zopiclone be used during pregnancy? Answer: Zopiclone should not be used during pregnancy as it may affect the developing baby. Question: Can Zopiclone be used during breastfeeding? Answer: Zopiclone passes into breast milk. Consult a healthcare professional before using it during breastfeeding. Question: Can children use Zopiclone? Answer: Zopiclone is not recommended for patients under 18 years of age. Question: How should Zopiclone be stored? Answer: Store Zopiclone at 15°C to 30°C in a dry place, protect from light, and keep out of reach of children.