৳ 14/unit
Pack: ৳ 14
৳ 14/unit
Pack: ৳ 14
At a glance
Desferrioxamine Mesilate is an iron chelator used for the treatment of acute iron poisoning, chronic iron overload, and aluminum overload.
Indications
- Acute iron poisoning
- Chronic iron overload (transfusion-dependent anemias)
- Aluminum overload (in ESRF patients on dialysis)
Pharmacology
Deferoxamine has a high affinity for ferric iron and forms chelates or stable water-soluble complexes with iron and other trivalent metal ions eg, aluminum. It removes free and bound iron from haemosiderin and ferritin, increasing the excretion of iron in urine and bile.
Dosage
Adult - Chronic iron overload: 20-60 mg/kg/day SC/IV infusion (3-7 times weekly).
Adult - Acute iron poisoning: 15 mg/kg/hr slow IV infusion (max 80 mg/kg/24hr) OR 2 g IM single dose.
Adult - Aluminum overload: 5 mg/kg once weekly (during last hour of dialysis or 5 hr before).
Side effects
Common: Rapid IV injection: Flushing, urticaria, hypotension and shock; SC/IM injection: Local pain; Prolonged SC: Pruritus, erythema and swelling; GI disorders, dysuria, fever, allergic skin rashes, tachycardia, cardiac arrhythmias, convulsions, leg cramps; visual disturbances, cataract formation, hearing loss; Pulmonary syndrome with high IV doses.
Use in pregnancy
Desferrioxamine may be unsafe during pregnancy. Please consult your doctor.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Impaired renal function; may color urine reddish-brown; may exacerbate aluminum-related encephalopathy and precipitate seizure; susceptible to infection; monitor urinary excretion of iron, ophthalmological, audiological and cardiac function.
Overdose effects
No adequate information on overdose is available. Seek medical attention.
Storage conditions
Store below 25°C.