Matropin

• Eye examination: for mydriasis and cycloplegia
• Uveitis

Homatropine is a competitive muscarinic receptor antagonist with a bulky aromatic group in place of the acetyl group of acetylcholine. It acts in similar manner as atropine, producing similar parasympatholytic effects. By blocking muscarinic receptors and cholinergic signalling pathways, homatropine blocks the response of the iris sphincter muscle and causes mydriasis. It also blocks the accommodative muscle of the ciliary body to cholinergic stimulation.

Adult Dose:

• For refraction: 1-2 drops of 2% solution, may repeat at 10-15 min intervals (max 5 doses)
• Uveitis: 1-2 drops of 2% bid-tid up to every 3-4 hours as needed

Child Dose:

• Refraction: 1 drop of 2% solution, repeat at 10-min intervals if necessary
• Uveitis (>2 years): 1 drop of 2% solution bid

Under 3 months: Do not use

* Use as directed by the registered physician

Common Side Effects:

• Eye irritation
• Stinging sensation
• Hypersensitivity - may cause conjunctivitis

Use in Pregnancy: May be unsafe during pregnancy. Animal studies have shown harmful effects.

Precautions:

• Do not use in closed-angle glaucoma or narrow angle between iris and cornea
• Caution in prostatic enlargement, paralytic ileus or pyloric stenosis
• Apply pressure on corner of eye for 1 minute after instilling
• Use within 4 weeks of opening

Overdose: Overdose is unlikely when used as directed. Excessive use may cause eye irritation.

Storage: Store in a cool and dry place, protect from light. Do not use longer than 30 days after first opening. Keep out of reach of children.