Maxsulin R Penset100IU/ml

• Diabetes mellitus (Type 1 and Type 2)
• Diabetic ketoacidosis

Adult Dose (Subcutaneous):

• Type 1 Diabetes: Initial: 0.2-0.4 units/kg/day divided q8hr; Maintenance: 0.5-1 unit/kg/day divided q8hr
• Type 2 Diabetes: Initial: 0.2-0.4 units/kg/day divided q8hr-q12hr
• 50-75% of total daily insulin given as intermediate- or long-acting insulin in 1-2 injections; rapid- or short-acting insulin used before or at mealtimes

Diabetic Ketoacidosis (IV):

• Loading dose: 20 units, then 6 units/hr until blood glucose drops to 10 mmol/l, then 3 units/hr

Child Dose (Type 1): Initial: 0.2-0.4 units/kg/day q8hr; Maintenance: 0.5-1 unit/kg/day; adolescents up to 1.5 units/kg/day

Side Effects:

• Hypoglycemia
• Injection site reactions (redness, swelling, pain)
• Lipodystrophy
• Pruritus
• Rash
• Lipoatrophy
• Hypokalemia
• Blurred vision
• Insulin resistance
• Headache
• Influenza-like symptoms
• Dyspepsia
• Diarrhea
• Back pain
• Pharyngitis

Precautions:

• Pregnancy (insulin requirements fall in 1st trimester, increase in 2nd and 3rd) and lactation
• Caution with decreased insulin requirements: Diarrhea, nausea/vomiting, malabsorption, hypothyroidism, renal impairment, hepatic impairment
• Hypokalemia may occur
• Caution in renal and hepatic impairment (dosage requirements may be reduced)
• Caution with increased insulin requirements: Fever, hyperthyroidism, trauma, infection, surgery
• Only soluble insulin can be administered IV