Megarin IV Injection25000IU/5ml

• Prophylaxis and treatment of venous thromboembolism and pulmonary embolism
• Atrial fibrillation with embolization
• Acute and chronic consumptive coagulopathies (disseminated intravascular coagulation)
• Prevention of clotting in arterial and cardiac surgery
• Prophylaxis and treatment of peripheral arterial embolism
• Anticoagulant use in blood transfusions, extracorporeal circulation, dialysis procedures and catheter patency

Therapeutic Anticoagulant Effect (Full-Dose Heparin):

Deep Subcutaneous (Intrafat) Injection:

• Initial Dose: 333 units/kg
• Every 12 hours: 250 units/kg

Intermittent Intravenous Injection:

• Initial Dose: 10,000 units
• Every 4-6 hours: 5,000-10,000 units

Continuous Intravenous Infusion:

• Initial Dose: 5,000 units (IV injection)
• Continuous: 20,000-40,000 units/24 hours

Heart and Blood Vessel Surgery:

• ≥ 150 units/kg

Catheter Patency Maintenance:

• 2 units/mL (infusion rate 3 mL/hour)

* Use as directed by the registered physician

Common Side Effects (>10%):

• Heparin-induced thrombocytopenia (10-30%)

Other Side Effects:

• Mild pain at injection site, hematoma, hemorrhage, local irritation, erythema
• Increased liver aminotransferase
• Anaphylaxis
• Immune hypersensitivity reaction
• Osteoporosis (long-term, high-dose use)

Serious (Potentially Fatal): HIT with or without thrombosis; bleeding

Precautions:

• Notify doctor if you see blood in urine or stool or any unusual bleeding
• Inform doctor if you experience rash, itching, swelling of face, tongue and throat
• Regular platelet counts, hematocrits and stool occult blood tests are recommended
• Caution in active bleeding, thrombocytopenia, peptic ulcer, cerebrovascular disorders, severe hypertension