Merin10mg
Rx- Generic:
- Domperidone
- Company:
- Edruc Ltd.
- Dosage form:
- Tablet
- Pack size:
- Tablet
৳ 1.50/unit
Pack: ৳ 1.50
At a glance
Domperidone — brands, prices, indication, dosage and side effects available in Bangladesh.
Description
Domperidone is a prescription medicine used in the treatment of indigestion, nausea and vomiting. It blocks the substance on the brain that triggers nausea or vomiting and it also increases the movement of food in the stomach, thereby improves digestion. Domperidone is taken before meals in a dose and duration as advised by the doctor. The dose you are given will depend on your condition and how you respond to the medicine. You should take this medicine until your doctor tells you to stop. Let your doctor know about all other medications you are taking as some may affect, or be affected by this medicine. The most common side effects are headache, dry mouth, and stomach pain. Most of these are temporary and usually resolve with time. Contact your doctor straight away if you are at all concerned about any of these side effects. It also causes dizziness and sleepiness, so do not drive or do anything that requires mental focus until you know how this medicine affects you. Avoid drinking alcohol while taking this medicine as it can worsen your sleepiness. This medicine may also cause diarrhea, so it is better to take plenty of fluids while taking this medicine as it may help to prevent dehydration. Before taking this medicine you should let your doctor know if you have liver or kidney problems. You shouldn't take it at the same time as an antacid. Pregnant women should also consult their doctor. You should avoid this medicine if suffering from bleeding ulcers of stomach. Domperidone is a prokinetic. It works on the region in the brain that controls vomiting. It also acts on the upper digestive tract to increase the movement of the stomach and intestines, allowing food to move more easily through the stomach.
Indications
• Indigestion • Nausea • Vomiting
Mechanism of action
Domperidone is a peripheral dopamine-receptor blocker. It increases oesophageal peristalsis, enhances gastroduodenal coordination and lowers oesophageal sphincter pressure, gastric motility and peristalsis, thus facilitating gastric emptying and decreasing small bowel transit time.
Dosage
Adult Dose: Oral Adults: Nausea and vomiting 10-20 mg 4-8 hrly. Max: 80 mg/day. Non ulcer dyspepsia 10 mg 3-4 times daily. Max: 20 mg 3-4 times daily. Last dose to be taken at bedtime. Migraine 20 mg 4 hrly. Max: 4 doses/24 hr. Rectal: Nausea and vomiting 60 mg twice daily. Elderly: No dosage adjustment needed. Hepatic impairment: No dosage adjustment needed. Child Dose: Oral Children : 0.2 - 0.4 mg/kg every 4 - 8 hours daily. Rectal Child: 15 kg: 30 mg bid; >12 yr >35 kg: 60 mg bid. Renal Dose: Renal impairment: Mild to moderate: No dosage adjustment needed. Severe: Reduce dosing to 1-2 times daily w/ prolonged treatment.
Administration
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Domperidone is to be taken empty stomach.
Missed dose
If you miss a dose of Domperidone, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular schedule. Do not double the dose.
Side effects
Common: • Headache • Dryness in mouth • Stomach pain • Diarrhea
Precautions & warnings
[UNSAFE] Domperidone may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Domperidone helps relieve nausea, vomiting and indigestion. It should be taken before meals as per the dose and duration prescribed by your doctor. It may cause dizziness and sleepiness. Do not drive or do anything that requires mental focus until you know how it affects you. Avoid consuming alcohol when taking Domperidone as it may cause excessive drowsiness. Dry mouth may occur as a side effect. Frequent mouth rinses, good oral hygiene, increased water intake and sugarless candy may help. Inform your doctor if you get watery diarrhea, fever, or stomach pain that does not go away. Do not take it for longer than 7 days without consulting your doctor.
Contraindications
Hypersensitivity. GI haemorrhage, obstruction and perforation, patients with prolactin releasing pituitary hormone, chronic admin or routine prophylaxis of postoperative nausea and vomiting.
Drug interactions
May antagonise the hypoprolactinaemic effect of bromocriptine. May antagonise the prokinetic effect w/ opioid analgesics and antimuscarinics. Potentially Fatal: Potent CYP3A4 inhibitors (e.g. ketoconazole, erythromycin or ritonavir) may increase serum domperidone levels and subsequently increasing the risk of QT prolongation.
Food interactions
[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Domperidone. Please consult your doctor.
Use in pregnancy
[CONSULT YOUR DOCTOR] Domperidone may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Use in lactation
[SAFE IF PRESCRIBED] Domperidone is safe to use during breastfeeding. Human studies suggest that the drug does not pass into the breastmilk in a significant amount and is not harmful to the baby.
Renal / hepatic impairment
[CAUTION] Domperidone should be used with caution in patients with kidney disease. Dose adjustment of Domperidone may be needed. Please consult your doctor. [CAUTION] Domperidone should be used with caution in patients with liver disease. Dose adjustment of Domperidone may be needed. Please consult your doctor. Use of Domperidone is not recommended in patients with moderate and severe liver disease.
Common questions
NAUSEA AND VOMITING DUE TO COLD Tab Domstal 1 tab Stat and keep yourself warm What is the medicine to stop vomiting? Caused due to indigestion. Suggest me medicine for this sir Tab Domstal 1 Stat What are some vomiting, headache,stomach pain, gas, fever tablets Tab crocin for pain and fever. Tab meftal spas for pain stomach. Tab domstal 10mg for vomiting. Vomiting after almost every meal and half headache, nausia Tab domstal 10mg before meals for vomiting.Tab crocin for headache.Consult a doctor If it persists I visited hill station after i suffer nausea Tab Domstal 1 tab stat Vomiting with some white material Tab Domstal 1 tab Stat Vomiting tendencies, low apetite Tab Domstal 1 Stat Fever since 7 days and also nausea and vomiting Tab Pacimol 1 tab SOS and Tab Domstal 1 tab STAT and1 tab SOS. Sine the fever has 7 days of history you must visit your Doctor