Methigic 2

• Rheumatic Disorders (Rheumatoid Arthritis, Ankylosing Spondylitis, Gouty Arthritis)
• Collagen Diseases (Systemic Lupus Erythematosus, Dermatomyositis)
• Dermatologic Diseases (Pemphigus, Exfoliative Dermatitis, Psoriasis)
• Allergies (Bronchial Asthma, Contact Dermatitis)
• Ophthalmic Diseases (Iritis, Keratitis, Allergic Conjunctivitis)
• Respiratory Diseases (Sarcoidosis, Aspiration Pneumonitis)
• Hematologic Disorders (Idiopathic Thrombocytopenic Purpura, Hemolytic Anemia)
• Neoplastic Diseases (Leukemias, Lymphomas)
• Edematous States (Nephrotic Syndrome)
• CNS Diseases (Multiple Sclerosis)
• Endocrine Disorders (Adrenocortical Insufficiency)

Adult Dose (Oral):

• Anti-inflammatory/Immunosuppressive: Initial: 4-48 mg daily (1-4 divided doses as needed)
• Allergic Conditions: 24 mg (Day 1), 20 mg (Day 2), 16 mg (Day 3), 12 mg (Day 4), 8 mg (Day 5), 4 mg (Day 6)
• Maintenance: Lowest effective dose based on patient response
• Multiple Sclerosis: 160 mg daily for 1 week, then 64 mg every other day for 1 month

Child Dose: 0.5-1.7 mg/kg daily or 5-25 mg/m² daily (6-12 hourly intervals)

Alternate-day therapy (ADT): Twice the daily dose every other morning (to minimize side effects in long-term use)

Common Side Effects:

• Skin thinning
• Increased risk of infection
• Reduction in bone density
• Weight gain
• Mood changes
• Upset stomach
• Behavioral changes

Long-term/High-dose:

• Fluid retention, weight gain, hypertension
• Potassium loss, headache
• Muscle weakness, osteoporosis
• Glaucoma, cataracts
• Peptic ulcer, growth retardation (children)
• Convulsions, psychiatric disorders (depression, euphoria, insomnia)

• Do not stop abruptly (risk of adrenal insufficiency)
• Inform doctor if signs of infection (fever, sore throat) occur
• Do not receive live vaccines
• Monitor blood glucose if diabetic
• Caution in osteoporosis, mood disorders, hypertension, liver disease
• Enhanced effect in hypothyroidism and cirrhosis