৳ 4,000/unit
Pack: ৳ 4,000
৳ 4,000/unit
Pack: ৳ 4,000
At a glance
Micafungin Sodium is an antifungal drug used for treatment of Candida infections and prophylaxis in stem cell transplant patients.
Indications
- Treatment of Candidemia and Acute Disseminated Candidiasis
- Treatment of Esophageal Candidiasis
- Prophylaxis of Candida Infections in Hematopoietic Stem Cell Transplant Patients
Pharmacology
Micafungin Sodium inhibits 1,3-β-D-glucan synthesis in fungal cell wall disrupting cell wall integrity and causing cell death.
Dosage
Adults and Children ≥4 months:
- Invasive Candidiasis: >40 kg: 100 mg/day; ≤40 kg: 2 mg/kg/day
- Esophageal Candidiasis (≥16 years): >40 kg: 150 mg/day; ≤40 kg: 3 mg/kg/day
- Prophylaxis: >40 kg: 50 mg/day; ≤40 kg: 1 mg/kg/day
Children <4 months:
- Invasive Candidiasis: 4-10 mg/kg/day
- Prophylaxis: 2 mg/kg/day
No loading dose required.
Side effects
Common Side Effects:
- Diarrhea
- Nausea and vomiting
- Pyrexia
- Hypokalemia
- Thrombocytopenia
- Headache
Histamine-mediated Reactions:
- Rash and pruritus
- Facial swelling
- Vasodilation
Use in pregnancy
Use in Pregnancy: No adequate controlled studies. Use only if clearly needed.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Discontinue if anaphylaxis occurs
- Monitor for intravascular hemolysis and hemolytic anemia
- Monitor liver function test abnormalities
- Caution in renal dysfunction
Overdose effects
Micafungin is highly protein bound and not dialyzable. No overdose cases reported. Doses up to 8 mg/kg used in clinical trials.
Storage conditions
Before Reconstitution: Store below 30°C. After Reconstitution: Store below 30°C; use within 24 hours.