Neoral 100

• Prevention of organ rejection in transplant patients
• Rheumatoid arthritis
• Psoriasis
• Atopic dermatitis
• Nephrotic syndrome

Ciclosporin is a strong immunosuppressant that acts mainly on the helper T-cells. It inhibits the activation of calcineurin and production of interleukin-2, thus reducing cell-mediated immune response.

Adult - Immunosuppression in organ transplantation (Oral): Initially: 10-15 mg/kg/day, starting 4-12 hr before procedure and continued for 1-2 wk; usual maintenance: 2-6 mg/kg/day. Lower doses may be used when combined with other immunosuppressants.

Adult - Psoriasis: Initially: 2.5 mg/kg/day, in 2 divided doses. Reduce to lowest effective dose once remission is achieved. Stop treatment if no sufficient improvement to max dose within 6 wk. Max: 5 mg/kg/day.

Adult - Rheumatoid arthritis: 2.5 mg/kg/day, in 2 divided doses. Treatment should continue for 6-8 wk. If response is insufficient, may increase dose gradually. Max: 4 mg/kg/day.

Adult - Nephrotic syndrome: 5 mg/kg daily, given in 2 divided doses.

Adult - Immunosuppression in organ transplantation (IV): Initially: 5-6 mg/kg/day as a single dose, infuse over 2-6 hr. Switch to oral dosage form as soon as possible.

Child - Nephrotic syndrome: 6 mg/kg daily, given in 2 divided doses.

Common Side Effects:

• Headache
• Nausea
• Vomiting
• Increased hair growth
• High blood pressure
• Renal dysfunction
• Loss of appetite
• Diarrhea
• Tremor
• Increased risk of infections

Serious Side Effects:

• Nephrotoxicity
• Hepatotoxicity
• Malignancy (especially skin cancer)
• Hypertension
• Neurotoxicity

Cyclosporine may be unsafe during pregnancy. Animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it. Please consult your doctor.

• Increased risk of infections due to weakened immune system. Tell your doctor if you develop an infection.
• Increased risk of skin cancer; limit exposure to sunlight.
• May affect your ability to drive.
• Regular blood tests are required to monitor blood pressure, liver and kidney function, and mineral levels.
• Drink 8-10 glasses of water per day.
• Do not stop taking Cyclosporine without talking to your doctor first.

No adequate information on overdose is available. Overdose may lead to nephrotoxicity, hepatotoxicity and other toxic effects. Consult your doctor if symptoms appear.

Store below 30°C temperature, away from light & moisture. Keep out of reach of children.