৳ 720/unit
Pack: ৳ 720
৳ 720/unit
Pack: ৳ 720
At a glance
Biphasic Insulin Aspart is used to improve glycemic control in adults and children with type 1 diabetes mellitus and in adults with type 2 diabetes mellitus.
Indications
- Type 1 diabetes mellitus (adults and children)
- Type 2 diabetes mellitus (adults)
Pharmacology
Insulin Aspart Biphasic is a biphasic suspension of soluble insulin aspart (rapid-acting) and protamine-crystallised insulin aspart (intermediate-acting). The primary activity of insulin is regulation of glucose metabolism. Insulin lowers blood glucose by stimulating peripheral glucose uptake (primarily by skeletal muscle and fat) and by inhibiting hepatic glucose production. Insulin inhibits lipolysis and proteolysis and enhances protein synthesis.
Dosage
Adult Dose (Subcutaneous):
- Insulin naive patients (Type 2): Recommended starting dose: 6 Units at breakfast and 6 Units at dinner; OR 12 units at dinner once daily
- Intensification: Once daily to twice daily (when reaching 30 units); Twice daily to thrice daily (split morning dose if recurrent daytime hypoglycemia)
- Dose adjustment: Based on lowest pre-meal blood glucose from previous 3 days; adjust once weekly; do not increase if hypoglycemia occurred within 3 days
Child Dose: Safety and efficacy not established
Side effects
>10%:
- Hypoglycemia (47-69%)
- Headache (12-35%)
- Influenza-like symptoms (12-13%)
1-10%:
- Dyspepsia (9%)
- Diarrhea (7-8%)
- Back pain (7%)
- Pharyngitis (6-7%)
Frequency Not Defined: Insulin resistance, Lipodystrophy, Lipohypertrophy, Local allergic reaction, Hypokalemia, Weight gain, Peripheral edema
Use in pregnancy
Use in Pregnancy: Category B; insulin requirements fall during 1st trimester, increase during 2nd and 3rd; regular monitoring of glucose control essential; advise patients to tell physician if they intend to become or become pregnant.
Pregnancy Category: B — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Rapid changes in serum glucose may induce symptoms of hypoglycemia
- Early warning symptoms of hypoglycemia may be different or less pronounced under certain conditions (long duration of diabetes, diabetic nerve disease, beta-blockers, intensified diabetes control)
- Caution in conditions with decreased insulin requirements (diarrhea, nausea/vomiting, malabsorption, hypothyroidism, renal impairment, hepatic impairment)
- Caution in conditions with increased insulin requirements (fever, hyperthyroidism, trauma, infection, surgery)
- Hypokalemia may occur; caution with potassium-lowering drugs
- Frequent glucose monitoring and insulin dose reduction may be required with renal or hepatic impairment
Overdose effects
Overdose: May result in hypoglycemia; mild episodes treated with oral carbohydrates; severe hypoglycemia treated with parenteral glucose or glucagon injections; adjustments in drug dosage, meal patterns, or exercise may be needed.
Storage conditions
Store at 2°C to 8°C in refrigerator; do not freeze; during use can be kept at room temperature for 1 month; keep away from heat and light.