NPH
Rx৳ 60.23/unit
Pack: ৳ 60.23
৳ 60.23/unit
Pack: ৳ 60.23
At a glance
Hydrocortisone + Neomycin Sulphate + Polymixin B E/E prep is used for bacterial ear infections and ocular inflammation with suspected or confirmed bacterial infection.
Indications
- Otitis externa (outer ear infection)
- Ocular inflammation with suspected or confirmed bacterial infection
Pharmacology
Neomycin, an aminoglycoside, binds to the 30S subunits of the bacterial ribosome, inhibiting protein synthesis and thereby disrupting DNA synthesis. Polymyxin B disrupts bacterial cell membrane and has bactericidal action against most Gram-negative bacilli. Hydrocortisone, a corticosteroid with mainly glucocorticoid activity, suppresses inflammatory response.
Dosage
Adult Dose (Otic/Aural):
- Neomycin sulfate 3.5 mg, polymyxin B sulfate 10,000 units, hydrocortisone 10 mg (1%) per ml: Instill 4 drops into affected ear 3-4 times daily
- Instill drop with the affected ear upward and remain in this position for 5 minutes
Child Dose (2-16 years):
- Instill 3 drops into affected ear 3-4 times daily
Ophthalmic Dose:
- 1-2 drops every 3-4 hours
Side effects
Ophthalmic:
- Irritation
- Increased intraocular pressure
- Glaucoma
- Posterior subcapsular cataract formation
- Delayed wound healing
- Secondary infections
Otic: Burning and stinging (if product enters the middle ear)
Use in pregnancy
No adequate information regarding use in pregnancy; consult your doctor.
Precautions & warnings
Precautions:
- Ophthalmic: Monitor intraocular pressure if used for >10 days
- Otic: Limit use to ≤10 days to reduce risk of ototoxicity
- Caution in pre-existing nerve deafness
Overdose effects
No information on overdose; do not exceed the recommended dose.
Storage conditions
Store in a cool and dry place, protected from light; keep out of reach of children.