৳ 7.04/unit
Pack: ৳ 70.40
৳ 7.04/unit
Pack: ৳ 70.40
At a glance
Pentoxifylline is a peripheral vasodilator used for the treatment of peripheral vascular disease (poor circulation to the arms and legs) and intermittent claudication (pain on walking or at rest caused by poor circulation to the legs). It improves blood flow by decreasing blood viscosity.
Indications
- Peripheral arterial occlusive disease (PAOD) of arteriosclerotic or diabetic origin (with intermittent claudication and rest pain)
- Trophic lesions (e.g., leg ulcers and gangrene)
- Cerebral vascular diseases
- Circulatory disturbances of the eye in conjunction with degenerative vascular disorders
Pharmacology
Pentoxifylline reduces blood viscosity, improves erythrocyte flexibility, and increases leukocyte deformability. It inhibits neutrophil adhesion and activation and enhances tissue oxygenation.
Dosage
Adult Dose (Oral):
- Usual dose: 400 mg 2-3 times daily (modified-release)
- Normally for at least 8 weeks
- May reduce to 400 mg twice daily if GI or CNS adverse effects occur
- Dose reduction may be needed in severe hepatic impairment
- Renal impairment (CrCl ~60 mL/min): 400 mg twice daily; (CrCl ~20 mL/min): 400 mg once daily; may reduce to 400 mg every other day if needed
Pediatric Dose: Safety and efficacy not established.
Side effects
Common Side Effects:
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Abdominal distension
- Heartburn
- Stomach discomfort
- Flushing
- Headache
- Dizziness
- Weakness
- Lightheadedness
Use in pregnancy
Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects. Doctor will weigh benefits and risks before prescribing.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
- May decrease alertness, affect vision, or cause sleepiness and dizziness; do not drive if these occur
- Caution in severe cardiac arrhythmias, myocardial infarction, hypotension
- Caution in renal impairment (CrCl <30 mL/min) and severe hepatic impairment
- Caution with anticoagulants, antiplatelet agents, antidiabetic agents, ciprofloxacin, theophylline
- Increased bleeding risk
- Avoid use during pregnancy and lactation
Overdose effects
Initial symptoms of acute overdose: nausea, dizziness, tachycardia, or fall in blood pressure. Other signs: fever, agitation, flush, loss of consciousness, areflexia, tonic-clonic convulsions, coffee-ground vomiting (GI bleeding). No specific antidote; gastric lavage and activated charcoal.
Storage conditions
Store in a cool and dry place, away from light; do not use after expiry date; keep out of reach of children.