Platosin1mg/ml

Cisplatin is used in the treatment of ovarian, cervical and testicular cancer. It shows its working by stopping or slowing down the growth of cancer cells. Cisplatin is given as an injection into veins by a qualified medical professional. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Injection site reaction (pain, swelling, redness), nausea and vomiting are some common side effects of this medicine. Hearing problem or ear damage is serious side effect of this medicine, hence your doctor might check you for hearing test before and after the treatment. This medicine may reduce the number of blood cells (decrease red blood and white blood cells) in your blood, thereby, increasing the susceptibility to infections. Regular blood tests are required to check your blood cells along with heart, liver, and kidney. Before taking this medicine, let your doctor know about kidney disease as medicine affect the functioning of the kidney. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. It makes men infertile, hence men should take doctor advice about the freezing of sperm before the treatment. Cisplatin is an anti-cancer medication. It works by damaging the genetic material (DNA and RNA) of the cancer cells which stops their growth and multiplication.

• Ovarian cancer • Cervical cancer • Testicular cancer

Cisplatin modifies cell cycle by interfering with DNA structure and function. Effects are most prominent during the S phase but cells are killed at all stages. Cisplatin synergises with other anticancer drugs e.g. fluorouracil. It has a narrow therapeutic margin and is highly toxic.

Adult Dose: Metastatic Testicular Tumors Usual dose in combination with other approved chemotherapeutic agents is 20 mg/m²/day IV for 5 days/cycle Pretreatment hydration: 1-2 L fluid infused for 8-12 hr before dose May use concomitant amifostine to decrease nephrotoxicity Do not repeat course until SCr 4000/mm³ AND platelets >100 k/mm³ Advanced Bladder Cancer 50-70 mg/m² IV cycle q3-4Weeks, depending on prior radiation therapy or chemotherapy; for heavily pretreated patients, give 50 mg/m²/cycle initially; repeat q4Weeks Pretreatment hydration: 1-2 L fluid infused for 8-12 hr before dose May use concomitant amifostine to decrease nephrotoxicity Do not repeat course until SCr 4000/mm³ AND platelets >100 k/mm³ Metastatic Ovarian Carcinoma 75-100 mg/m² IV per cycle q4Weeks with cyclophosphamide (600 mg/m² IV q4Weeks); administer sequentially Off-label: 90-270 mg/m² intraperitoneal; retain for 4 hr before draining; repeat q3Weeks (may coadminister systemic Na thiosulfate) Pretreatment hydration: 1-2 L fluid infused for 8-12 hr before dose May use concomitant amifostine to decrease nephrotoxicity Do not repeat course until SCr 4000/mm³ AND platelets >100 k/mm³ Renal Dose: Renal Impairment CrCl 10-50 mL/min: Decrease dose 50% CrCl <10 mL/min: Contraindicated

Your doctor or nurse will give you this medicine. Kindly do not self-administer.

If you miss a dose of Cisplatin, please consult your doctor.

Common: • Injection site reactions (pain, swelling, redness) • Increased risk of infection • Ear disorder • Vomiting • Nausea • Decreased blood cells (red cells, white cells, and platelets) • Renal impairment • Peripheral neuropathy (tingling and numbness of feet and hand) • Kidney damage • Hearing loss • Ringing in ear

[UNSAFE] Cisplatin may cause side effects which could affect your ability to drive. Cisplatin may cause side effects such as feeling sleepy and/or vomiting which could affect your ability to drive. Cisplatin is given as an injection under the supervision of a doctor.

Patients with severe renal or auditory disorder, known hypersensitivity, severe bone marrow suppression, peripheral neuropathy, pregnancy, lactation.

Synergistic with 5-fluorouracil and etoposide. Efficacy increased and toxicity reduced when combined with radioprotecting agent WR 2721. At doses ?100 mg, cisplatin is an ideal drug to combine with other cytotoxic drugs; unlike other antineoplastic drugs, it causes little myelosuppression. Potentially Fatal: Potentiates nephrotoxicity with aminoglycosides. Increased toxicity when combined with other cytotoxic drugs.

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Cisplatin. Please consult your doctor.

[CONSULT YOUR DOCTOR] Cisplatin is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[UNSAFE] Cisplatin is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

[CAUTION] Cisplatin should be used with caution in patients with kidney disease. Dose adjustment of Cisplatin may be needed. Please consult your doctor. Use of Cisplatin is not recommended in patients with severe kidney disease. [SAFE IF PRESCRIBED] Cisplatin is probably safe to use in patients with liver disease. Limited data available suggests that dose adjustment of Cisplatin may not be needed in these patients. Please consult your doctor.

Sir my brother have skin cancer can you do something for save his life ?? Treatment of cancer depends on whether it is localized or metastatic cancer How we can find out parient is CA and which report we can do for know the patient is CA Thr is no single test for cancerWhich cancer ur looking for ovarian cancer stage 3 c surgery done chemotheraphy done C?se has to be seen in person before starting the treatment I am having recurring tongue and throat ulcers for the last 5 months. I have consulted with ENT Specialist. But presently noticed my right side tonsil is enlarged. Is it cancer? It may be a cancer or infection first go to a cancer surgeon If any symtom of brest cancer if have whats the cure First is confirmation of breast cancerChance of cure depends on stage of cancer sir plZ explain it is it cancer or not? if thz is cancer then wht is expected life ?? Yes it&#x27;s cancer Smears show metastatic mucinous adenocarcinoma.HISTOPATHOLOGY REPORT.sir is there any treatment Sir my mom firstly suffered from stomach pain.Then say about doing ultra sound test which is as:Neoplasm Stomach Pylrus.Fresh blood in corpus .polypoid growth in pylrus biopy taken from HPE Sir please help doctors already said there is no treatment for this stomach cancer disease Cancer is treated based on stage of cancerPlease upload reports of Ultrasound and endoscopy I want to know the symptoms of cancer as I am a smoker Symptoms for cancer depends upon which organ involved. For smokers , definitely chronic , they have possibility to develop lung cancer, head and neck cancers, oesophagus cancer, pancreatic cancer, stomach cancer and so more on. General symptoms would be like loss of appetite, weight loss, low grade fever in some cases, chronic cough for long time.