৳ 2,250/unit
Pack: ৳ 2,250
৳ 2,250/unit
Pack: ৳ 2,250
At a glance
Chorionic Gonadotrophin is a polypeptide hormone used to induce ovulation in females and treat hypogonadism, cryptorchidism, and oligospermia in males.
Indications
- Anovulatory infertility & ovulation induction in females
- Preparation of follicles for puncture in controlled ovarian hyperstimulation programs (ART/IVF)
- Luteal phase support
- Threatened and habitual abortion
- Hypogonadotropic hypogonadism in males
- Delayed puberty associated with insufficient gonadotropic pituitary function
- Cryptorchidism (not due to anatomical obstruction)
- Oligospermia
Pharmacology
Pharmacodynamic Properties: Highly Purified Human Chorionic Gonadotrophin has LH activity. LH is indispensable in normal female and male gamete growth and maturation, and gonadal steroid production. In the female: hCG is given as a substitute for the endogenous mid-cycle LH surge to induce the final phase of follicular maturation, leading to ovulation. hCG is also given as a substitute for endogenous LH during the luteal phase. In the male: hCG is given to stimulate Leydig cells to promote the production of testosterone.
Dosage
Female Dose (IM):
| Indication | Dose | Schedule |
|---|---|---|
| Ovulation induction/follicle preparation | 5000-10000 IU | Single injection |
| Luteal phase support | 2500-5000 IU | Repeat on days 3, 6 and 9 after ovulation |
| Threatened/habitual abortion | 5000 IU | Twice weekly (before 7th week of gestation) |
Male Dose (IM):
| Indication | Dose | Schedule |
|---|---|---|
| Cryptorchidism | 500-4000 IU | 3 times weekly (1-2 months after testicular descent) |
| Hypogonadotropic hypogonadism/male infertility | 500-4000 IU | 2-3 times weekly |
| Delayed puberty (males) | Initial: 500-1500 IU | Twice weekly (titrated against plasma-testosterone) |
Side effects
Common Side Effects:
- Headache
- Irritability, restlessness
- Depression, fatigue
- Edema
- Pain at injection site
- Gynecomastia
- Abdominal pain
Serious Side Effects:
- Ovarian Hyperstimulation Syndrome (OHSS) - potentially fatal
- Precocious puberty (children)
- Enlargement and rupture of ovarian cysts
- Arterial thromboembolism
- Shock
Use in pregnancy
Pregnancy Category X. Studies in animals or human beings have demonstrated fetal abnormalities. Contraindicated during pregnancy.
Pregnancy Category: X — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Discontinue therapy if signs of precocious puberty are seen in patients treated for cryptorchidism.
- Patients with cardiac or renal disease, epilepsy, migraine or asthma require caution.
- Regular ultrasound and estrogen monitoring during FSH therapy to avoid ovarian hyperstimulation.
- Special caution in patients with polycystic ovarian disease.
- Contraindicated during pregnancy and lactation.
Overdose effects
Acute toxicity is very low. No symptoms of acute parenteral overdose are known in humans.
Storage conditions
Store at 2°C-8°C (in refrigerator). Do not freeze. Store below 25°C for a single period of not more than 3 months. Protect from light & keep in dry place.