Generic
Chorionic Gonadotrophin
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At a glance
Chorionic Gonadotrophin is a polypeptide hormone used to induce ovulation in females and treat hypogonadism, cryptorchidism, and oligospermia in males.
Description
Chorionic Gonadotrophin is a polypeptide hormone produced by the human placenta. It stimulates the production of gonadal steroid hormones by inducing interstitial cells (Leydig cells) of the testis to produce androgens and the corpus luteum of the ovary to produce progesterone. In females, it is given as a substitute for the endogenous mid-cycle LH surge to induce the final phase of follicular maturation leading to ovulation. In males, it is given to stimulate Leydig cells to promote testosterone production. This medicine is administered as an intramuscular injection under medical supervision.
Indications
- Anovulatory infertility & ovulation induction in females
- Preparation of follicles for puncture in controlled ovarian hyperstimulation programs (ART/IVF)
- Luteal phase support
- Threatened and habitual abortion
- Hypogonadotropic hypogonadism in males
- Delayed puberty associated with insufficient gonadotropic pituitary function
- Cryptorchidism (not due to anatomical obstruction)
- Oligospermia
Therapeutic class
Female Sex hormones
Pharmacological class
Gonadotropin Hormone (hCG)
Pharmacology
Pharmacodynamic Properties: Highly Purified Human Chorionic Gonadotrophin has LH activity. LH is indispensable in normal female and male gamete growth and maturation, and gonadal steroid production. In the female: hCG is given as a substitute for the endogenous mid-cycle LH surge to induce the final phase of follicular maturation, leading to ovulation. hCG is also given as a substitute for endogenous LH during the luteal phase. In the male: hCG is given to stimulate Leydig cells to promote the production of testosterone.
Mechanism of action
Chorionic Gonadotrophin stimulates Leydig cells of the testis to produce androgens and the corpus luteum of the ovary to produce progesterone. In females it induces ovulation as an LH surge substitute, and in males it increases testosterone production.
Dosage
Female Dose (IM):
| Indication | Dose | Schedule |
|---|---|---|
| Ovulation induction/follicle preparation | 5000-10000 IU | Single injection |
| Luteal phase support | 2500-5000 IU | Repeat on days 3, 6 and 9 after ovulation |
| Threatened/habitual abortion | 5000 IU | Twice weekly (before 7th week of gestation) |
Male Dose (IM):
| Indication | Dose | Schedule |
|---|---|---|
| Cryptorchidism | 500-4000 IU | 3 times weekly (1-2 months after testicular descent) |
| Hypogonadotropic hypogonadism/male infertility | 500-4000 IU | 2-3 times weekly |
| Delayed puberty (males) | Initial: 500-1500 IU | Twice weekly (titrated against plasma-testosterone) |
Administration
After reconstitution, administer slowly by intramuscular injection. Use under medical supervision.
Missed dose
If you miss a dose of Chorionic Gonadotrophin, please consult your doctor.
Side effects
Common Side Effects:
- Headache
- Irritability, restlessness
- Depression, fatigue
- Edema
- Pain at injection site
- Gynecomastia
- Abdominal pain
Serious Side Effects:
- Ovarian Hyperstimulation Syndrome (OHSS) - potentially fatal
- Precocious puberty (children)
- Enlargement and rupture of ovarian cysts
- Arterial thromboembolism
- Shock
Precautions & warnings
- Discontinue therapy if signs of precocious puberty are seen in patients treated for cryptorchidism.
- Patients with cardiac or renal disease, epilepsy, migraine or asthma require caution.
- Regular ultrasound and estrogen monitoring during FSH therapy to avoid ovarian hyperstimulation.
- Special caution in patients with polycystic ovarian disease.
- Contraindicated during pregnancy and lactation.
Contraindications
- Hypersensitivity
- Precocious puberty
- Prostatic carcinoma or other androgenic dependent neoplasm
- Pregnancy and lactation
Drug interactions
Interactions of Human chorionic gonadotrophin with other medicines have not been investigated. May interfere with immunological determination of serum/urinary hCG for up to 10 days, leading to a false positive pregnancy test. Must not be mixed with other medicinal products in the absence of compatibility studies.
Food interactions
No food interactions have been found or established.
Use in pregnancy
Pregnancy Category X. Studies in animals or human beings have demonstrated fetal abnormalities. Contraindicated during pregnancy.
Pregnancy Category: X — always consult a doctor before taking during pregnancy.
Use in lactation
Must not be used during lactation.
Pediatric use
Pediatric Use: Induction of androgen secretion by hCG may induce precocious puberty in pediatric patients treated for cryptorchidism. Therapy should be discontinued if signs of precocious puberty occur. Use cautiously in prepubertal boys to avoid premature epiphyseal closure or precocious sexual development. Skeletal maturation should be monitored regularly.
Geriatric use
Clinical studies did not include subjects aged 65 and over.
Renal / hepatic impairment
Caution required in cardiac or renal disease.
Overdose effects
Acute toxicity is very low. No symptoms of acute parenteral overdose are known in humans.
Storage conditions
Store at 2°C-8°C (in refrigerator). Do not freeze. Store below 25°C for a single period of not more than 3 months. Protect from light & keep in dry place.
Chemical structure
Human Chorionic Gonadotrophin