৳ 10/unit
Pack: ৳ 140
৳ 10/unit
Pack: ৳ 140
At a glance
Propylthiouracil is an anti-thyroid medication used for hyperthyroidism, particularly in patients with Graves' disease or toxic multinodular goiter who are intolerant of methimazole and for whom surgery or radioactive iodine therapy is not an appropriate treatment option.
Indications
- Graves' disease with hyperthyroidism or toxic multinodular goiter (methimazole-intolerant)
- Amelioration of hyperthyroidism symptoms in preparation for thyroidectomy or radioactive iodine therapy (methimazole-intolerant)
Pharmacology
Propylthiouracil inhibits thyroid hormone synthesis by preventing iodine oxidation in the thyroid gland. It also blocks peripheral deiodination of thyroxine (T4) to tri-iodothyronine (T3), which is effective in severe hyperthyroidism (thyroid storm).
Dosage
Adult Dose (Oral):
- Hyperthyroidism: 150-450 mg daily in divided doses; severe cases: 600-1200 mg daily initially; maintenance: 50-150 mg daily
- Hepatic impairment: Dose reduction recommended
- Treatment usually continued for 1-2 years
Pediatric Dose (Oral):
- Neonates: 2.5-5 mg/kg twice daily
- 1 month-1 year: 2.5 mg/kg three times daily
- 1-5 years: 25 mg three times daily
- 5-12 years: 50 mg three times daily
- 12-18 years: 100 mg three times daily
Side effects
Side Effects:
- Skin rash
- Urticaria
- Pruritus
- Abnormal hair loss
- Skin pigmentation
- Nausea, vomiting
- Arthralgia
- Myalgia
- Paresthesia
- Headache
- Leukopenia
- Agranulocytosis
- Hepatitis, hepatic failure
Use in pregnancy
Use in Pregnancy: Unsafe during pregnancy; may cause fetal goiter and hypothyroidism; use lowest possible dose; consult your doctor.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Risk of agranulocytosis; report sore throat, fever, mouth ulcers, malaise immediately
- Severe hepatic reactions (fatal) may occur; occurs within first 6 months; discontinue if liver enzyme abnormalities develop
- Monitor prothrombin time before surgery
- Use lowest possible dose during pregnancy
- Monitor neonatal development during lactation
Overdose effects
Overdose: Nausea, vomiting, epigastric distress, headache, fever, arthralgia, pruritus, edema, pancytopenia, agranulocytosis; treatment: supportive care.
Storage conditions
Store in a cool (below 30°C) and dry place, away from light and children.