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At a glance

Oxyphencyclimine Hydrochloride is an antimuscarinic used for peptic ulcer disease and smooth muscle spasms in gastrointestinal disorders. It blocks muscarinic receptors to antagonize acetylcholine action.

Indications
  • Peptic ulcer disease
  • Smooth muscle spasms in gastrointestinal disorders
Pharmacology

Oxyphencyclimine blocks all three types of muscarinic receptors to antagonize acetylcholine action, relaxing smooth muscle and relieving GI spasm.

Dosage

Adult Dose (Oral):

  • Peptic ulcer: 5-10 mg twice or three times daily
Side effects

Common Side Effects:

  • Xerostomia (dry mouth)
  • Decreased sweating
  • Urinary hesitancy and retention
  • Blurred vision
  • Cycloplegia
  • Increased ocular tension
  • Loss of taste
  • Headache
  • Nervousness
  • Mental confusion
  • Impotence
  • Suppression of lactation
  • Urticaria
  • Constipation
Use in pregnancy

Use in Pregnancy: Oxyphencyclimine may be unsafe during pregnancy; animal studies show adverse effects.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Caution in elderly; autonomic neuropathy; hepatic or renal disease; hyperthyroidism, CHF, thyrotoxicosis, MI, tachyarrhythmias, hypertension, prostatic hypertrophy; hiatal hernia
  • May impair ability to drive or operate machinery
  • Caution during pregnancy and lactation
Overdose effects

Overdose: Treatment same as for atropine overdosage.

Storage conditions

Store below 30°C, away from light & moisture; keep out of reach of children.

Oxyphencyclimine Hydrochloride — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.