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At a glance

Rabeprazole + Domperidone is a combination medicine used for gastroesophageal reflux disease (acid reflux) and peptic ulcer disease. Rabeprazole is a PPI that reduces stomach acid, and Domperidone is a prokinetic that increases upper digestive tract motility.

Indications
  • Gastroesophageal reflux disease (acid reflux)
  • Peptic ulcer disease
Pharmacology

Rabeprazole suppresses gastric acid secretion by inhibiting H+/K+ ATPase. Domperidone blocks peripheral dopamine receptors, increasing esophageal peristalsis, enhancing gastroduodenal coordination, and facilitating gastric emptying, relieving acid reflux and indigestion.

Dosage

Adult Dose (>12 years):

  • 1 capsule/tablet once daily (on empty stomach)
  • Treatment duration: 4-8 weeks
Side effects

Common Side Effects:

  • Diarrhea
  • Abdominal pain
  • Dry mouth
  • Headache
  • Dizziness
  • Flatulence
  • Weakness
  • Flu-like symptoms
Use in pregnancy

Use in Pregnancy: May be unsafe during pregnancy; animal studies have shown harmful effects; consult your doctor.

Pregnancy Category: C — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • May affect driving ability; do not drive if drowsy or dizzy
  • Avoid alcohol (excessive drowsiness)
  • Long-term use may cause weak bones and magnesium deficiency; take calcium and magnesium
  • Caution in severe liver disease
Overdose effects

No overdose information available; consult your doctor if taken in excess.

Storage conditions

Store in a cool and dry place, protected from light; keep out of reach of children.

Rabeprazole + Domperidone — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.