৳ 1,136/unit
Pack: ৳ 1,136
৳ 1,136/unit
Pack: ৳ 1,136
At a glance
Erythropoietin is an erythropoiesis-stimulating agent used for the treatment of anemia due to kidney disease, cancer chemotherapy, and HIV treatment.
Indications
- Anemia due to Chronic Kidney Disease: In patients on dialysis and not on dialysis.
- Zidovudine in HIV-infected Patients: Anemia prevention and treatment.
- Anemia due to Chemotherapy: Due to myelosuppressive chemotherapy effects.
- Reduction of Allogeneic RBC Transfusions: In elective, noncardiac, nonvascular surgery patients.
Pharmacology
Erythropoietin regulates erythropoiesis by stimulating the differentiation and proliferation of erythroid precursors, stimulating the release of reticulocytes into the circulation, and synthesis of cellular haemoglobin. Recombinant human erythropoietin is available as epoetin alfa and epoetin beta which are used in the management of anaemias associated with CRF, cancer chemotherapy and anti-AIDS drug zidovudine.
Dosage
Adult Dose:
- CKD-Associated Anemia (Not on dialysis): 50-100 units/kg IV/SC 3 times weekly; initiate when Hb <10 g/dL.
- CKD-Associated Anemia (On dialysis): 50-100 units/kg IV 3 times weekly; initiate when Hb <10 g/dL.
- Chemotherapy-Related Anemia: 150 units/kg IV/SC 3 times weekly or 40,000 units SC once weekly.
- Preparation for Surgery: 300 units/kg SC daily for 15 days or 600 units/kg SC in 4 doses.
Child Dose: As above.
Side effects
Common Side Effects:
- High blood pressure
- Nausea
- Fever
- Vomiting
- Headache
- Fatigue
- Dizziness
Use in pregnancy
Use in Pregnancy: Erythropoietin may be unsafe to use during pregnancy. Animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Erythropoietin may cause side effects which could affect your ability to drive.
- Helps in the treatment of anemia caused by chronic kidney disease or cancer chemotherapy.
- Your doctor may get your blood tests done regularly to monitor hemoglobin, blood cells and potassium levels.
- Monitor your blood pressure regularly while taking this medication.
- Inform your doctor if you notice severe headache, problems with eyesight, nausea, vomiting or seizures.
- Stop taking and inform your doctor if you develop shortness of breath or skin rash.
Overdose effects
Overdose: Overdose may cause hypertension, polycythemia, seizures, thrombosis. In case of overdose, seek immediate medical attention.
Storage conditions
Storage: Store in refrigerator at 2-8°C. Bring to room temperature before use. Do not freeze. Protect from light.