osudhkosh
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Company•Aristopharma Limited

Reumazin 500

Rx
Generic: Sulfasalazine

৳ 5.20/unit

Pack: ৳ 52

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At a glance

Sulfasalazine is a DMARD used for rheumatoid arthritis, ulcerative colitis, Crohn's disease, and ankylosing spondylitis. It suppresses immune system overactivity and blocks inflammatory mediators.

Indications
  • Rheumatoid arthritis
  • Juvenile idiopathic arthritis
  • Ulcerative colitis
  • Crohn's disease (especially with colonic involvement)
  • Ankylosing spondylitis
Pharmacology

Sulfasalazine is broken down in the intestine into 5-aminosalicylic acid (5-ASA) and sulfapyridine. 5-ASA provides local anti-inflammatory action by inhibiting leukotriene and prostaglandin synthesis; sulfapyridine provides systemic immunomodulatory effects. It inhibits both cyclooxygenase and lipoxygenase pathways, reducing production of inflammatory mediators.

Dosage

Adult Dose (Oral):

  • Ulcerative colitis/Crohn's: Start 1-2 g 4 times daily (until remission); Maintenance 2 g/day (divided)
  • Rheumatoid arthritis: Start 500 mg/day (week 1), increase by 500 mg weekly; max 3 g/day in 2-4 divided doses
  • Ankylosing spondylitis: 2 g/day in 2 divided doses

Pediatric Dose (Oral):

  • Ulcerative colitis (>2 years): 40-60 mg/kg/day (divided); Maintenance 20-30 mg/kg/day
  • Juvenile RA (>6 years): 30-50 mg/kg/day in 2 divided doses; max 2 g/day
Side effects

Common Side Effects:

  • Nausea, vomiting, diarrhea
  • Headache, loss of appetite
  • GI discomfort, weight loss
  • Oligospermia (reversible reduction in sperm count)
Use in pregnancy

Use in Pregnancy: Generally safe; animal studies show low or no adverse effects; limited human data; consult your doctor.

Pregnancy Category: D — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Do not use in hypersensitivity to sulfonamides or salicylates
  • Do not use in porphyria, intestinal or urinary obstruction
  • Do not use in children <2 years
  • Caution in G6PD deficiency, hepatic/renal impairment
  • Regular blood tests (liver, kidney function, blood counts) required
Overdose effects

No overdose information available; excessive doses may cause nausea, abdominal pain, diarrhea; provide symptomatic treatment.

Storage conditions

Store in a cool and dry place, protected from light; keep out of reach of children.

Sulfasalazine — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.