Rimactazid Z 450
Rx- Company:
- Nevian Lifescience PLC
- Dosage form:
- Tablet
- Pack size:
- Strip (10 Tablet)
৳ 11.74/unit
Pack: ৳ 117.40
At a glance
Isoniazid + Pyrazinamide + Rifampicin — brands, prices, indication, dosage and side effects available in Bangladesh.
Description
Isoniazid + Pyrazinamide + Rifampicin is a combination medicine used in the treatment of tuberculosis. It prevents the growth of the microorganisms that cause the infection. Isoniazid + Pyrazinamide + Rifampicin is a prescription medicine and it is to be taken it as suggested by the doctor. It should be taken in an empty stomach and take it at a fixed time to ensure better efficacy. Do not consume more than the recommended dose, as this may have harmful effects on your body. If you miss a dose, take it as soon as you remember. The course of the treatment must be completed even if you feel better. Sudden discontinuation of the treatment may affect the potency of the medicine. The medicine may take some to show its effects on the symptoms. However, it is advised to consult the doctor if you feel an aggravation of the condition or if your condition does not improve. Some common side effects of this medicine are nausea, vomiting, fever, dark-colored urine, sweating, increased saliva, etc. To cope up with the side effects, you should drink plenty of water. If any of the side effects get aggravated, you must consult your doctor immediately. Generally, serious side effects are rare. If you experience any allergic reaction (rashes, itching, swelling, shortness of breath, etc.), you must seek immediate medical help. Before taking this medicine, you should tell your doctor if you are taking any medicines for any health condition. Patients with liver and kidney ailments must take this medicine with proper consultation and caution. Pregnant or breastfeeding women should also consult with the doctor before taking it. Avoid drinking alcohol as it can cause excessive drowsiness with this medicine. It usually does not impair your ability to drive, but you should not drive if it makes you feel sleepy or dizzy. During the treatment, you must take adequate rest and eat a healthy diet for a faster recovery. While on the medication, your doctor may ask for a few laboratory and diagnostic tests to know the effects of the medicine on your body. Isoniazid + Pyrazinamide + Rifampicin is a combination of three medicines: Isoniazid, Pyrazinamide and Rifampicin which treat tuberculosis. Isoniazid prevents the TB bacteria from forming their own protective covering while Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by these bacteria to make essential proteins and to reproduce. Together, they kill the bacteria and eradicate the infection. Pyrazinamide, on the other hand works by slowing the growth of these bacteria.
Indications
• Tuberculosis (TB)
Mechanism of action
Isoniazid + Pyrazinamide + Rifampicin is a combination of three medicines: Isoniazid, Pyrazinamide and Rifampicin which treat tuberculosis. Isoniazid prevents the TB bacteria from forming their own protective covering while Rifampicin works by inactivating a bacterial enzyme (RNA-polymerase) which is required by these bacteria to make essential proteins and to reproduce. Together, they kill the bacteria and eradicate the infection. Pyrazinamide, on the other hand works by slowing the growth of these bacteria.
Administration
Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Isoniazid + Pyrazinamide + Rifampicin is to be taken empty stomach. Avoid Isoniazid + Pyrazinamide + Rifampicin with tyramine-rich food such as cheese, smoked fish, meats and some types of beer.
Side effects
Common: • Nausea • Vomiting • Fever • Rash • Dark colored urine • Sweating • Increased sputum production • Salivation • Watery eyes • Peripheral neuropathy (tingling and numbness of feet and hand) • Increased liver enzymes • Jaundice • Increased uric acid level in blood • Gout
Precautions & warnings
[UNSAFE] Isoniazid + Pyrazinamide + Rifampicin may cause side effects which could affect your ability to drive. You may feel dizzy or faint, have problems with vision or have other side effects that could affect your ability to drive.
Food interactions
[UNSAFE] Consuming alcohol while taking Isoniazid + Pyrazinamide + Rifampicin may cause symptoms such as flushing, increased heart beat, nausea, thirst, chest pain and low blood pressure (Disulfiram reaction).
Use in pregnancy
[CONSULT YOUR DOCTOR] Isoniazid + Pyrazinamide + Rifampicin may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.
Use in lactation
[SAFE IF PRESCRIBED] Isoniazid + Pyrazinamide + Rifampicin is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.
Renal / hepatic impairment
[CAUTION] Isoniazid + Pyrazinamide + Rifampicin should be used with caution in patients with kidney disease. Dose adjustment of Isoniazid + Pyrazinamide + Rifampicin may be needed. Please consult your doctor. [CAUTION] Isoniazid + Pyrazinamide + Rifampicin should be used with caution in patients with liver disease. Dose adjustment of Isoniazid + Pyrazinamide + Rifampicin may be needed. Please consult your doctor. Regular monitoring of liver function tests is advised before and after the start of the treatment.
Common questions
After having tuberculosis diagnosed she has been recommended to have R cinex EZ 2 tablets daily for 2 months then after 1tablet Risorine for 1 month and now doctor has recommended onceagain to have R cinex EZ 2tables on alternate days what to do. TB treatment is in 2 phases1. Intensive phase where tabs RHZE are given as in your case and in the second phase called continuation phase one one the medicines is stopped nad others continued.Please discuss with your doctor or see another doctor nearby for opinion since , the treatment may have to be modified, read about TB at http://www.arohealth.com/pulmonary-tuberculosis/ I am on ATT for TB treatment from 22 June 2016. Prescribed medicines are R-cinex 600mg, Pzide 1500mg, combutol 1200mg. Doctor has also prescribed Benadon tablet 20mg, rabloc tablet 20mg. I am having rabloc & R-cinex in early morning 5:30 am (empty stomach) & after light breakfast all the remaining tablets. How & when should I take my medicines so that one tablet doesn't contradict other? My liver ALT(SGPT) shot up to 149 on 1 july. asked to stop R-cinex till SGPT doesn't come down. I am want to know which tablet should be taken at which time i.e empty stomach/after light breakfast/lunch? Please help me out here! U are taking it correctly.It harms liver sometimes and therefore stopped and re started graduallyU can continue as per your doctor's advise Whats r Various pathological test for me tuberculosis???? Dear PATIENT various tests which you use for MDR Tuberculosis are: Genexpert test which basically detects the DNA of TB bacteria, microarrays, Phage assyas etc. She is on anti TB drugs since last 5 months 10 days , for initial two months she was taking forecox 2 tabs, thereafter she is continuing akurit 3 , 3 tablet, but some other advised us to take only one tab r cinex 450,so please advice akurit 3 must be taken in continuation phase What r d symptoms of Tuberculosis n which tests r there to confirm it? symptom is mainly Cough for more than 3 weeks , some time with blood also, weight loss, fever and weaknesstest is --- SPUTUM FOR AFB, CXR(PA view), ESR, CBC, Removal of Tumor from urinary tract was followed by 5 bcg 1 per week in November. A month back doctor gave r cinex. Now urination is giving trouble plus burning sensation has increased. cannot bear it. Show all ur reports