Rizamig 5

Rizatriptan is a prescription medicine used in the treatment of acute attack of migraine. It relieves the symptoms of migraine and prevents the attack from becoming worse. This medicine helps by narrowing the blood vessels, thereby relieving migraine headaches. Rizatriptan may be taken with or without food. However, it is advised to take it at the same time each day as this helps to maintain a consistent level of medicine in the body. Do not skip any doses and finish the full course of treatment even if you feel better and if you have missed a dose, take it as soon as you remember. You should continue to take this medicine for as long as doctor advises and do not stop taking it suddenly. Side effects associated with the use of this medicine include neck pain, dry mouth, sensation of heaviness, nausea, weakness, jaw pain, throat pain and paresthesia (tingling or pricking sensation). However, these are usually temporary and usually resolve on their own. Please consult your doctor if these do not subside or worry you. It may also cause sleepiness in the beginning of your treatment, so do not drive, operate machinery, until you know how this medicine affects you. This medicine may cause changes in your mood and you may feel depressed, therefore, regular monitoring of behavior is important. Pregnant or breastfeeding mothers should consult their doctor before taking this medicine. Inform your doctor if you are suffering from any heart problems, as the use of Rizatriptan is contraindicated in some heart diseases. Regular monitoring of blood pressure is required while taking this medicine. Consult your doctor and stop this medicine if you develop severe chest or stomach pain, bloody diarrhea, or significantly high blood pressure, after taking this medicine. Migraine headaches are thought to result from the dilatation of blood vessels in the head. Rizatriptan works by constricting (narrowing) these blood vessels, thereby relieving the migraine headaches.

• Acute migraine headache

Rizatriptan is a selective serotonin (5-HT1) agonist in cranial arteries responsible for vasoconstriction and reduction of inflammation associated with antidromic neuronal transmission.

Adult Dose: Oral Acute migraine attacks Adult: Initially, 10 mg. If ineffective, 2nd dose should not be taken for the same attack. If symptoms recur after initial response, a further dose of 10 mg may be given. Doses should be separated by at least 2 hr. Max: 20 mg/24 hr. If patient is also taking propanolol, initiate with 5 mg. Max: 10 mg/24 hr. Ensure that the 2 drugs are separated by at least 2 hr. Hepatic Impairment For mild-moderate impairment, initate with 5 mg. Further dose of 5 mg may be taken after an interval of at least 2 hr. Max: 10 mg/24 hr. Avoid in severe impairment. Child Dose: Migraine Headache Acute treatment of migraine with or without aura 40 kg) taking propranolol: Limit dose to 5 mg PO once q24hr as necessary; not to exceed 5 mg/24hr Renal Dose: Renal Impairment For mild-moderate impairment, initate with 5 mg. Further dose of 5 mg may be taken after an interval of at least 2 hr. Max: 10 mg/24 hr. Avoid in severe impairment.

Take this medicine in the dose and duration as advised by your doctor. Swallow it as a whole. Do not chew, crush or break it. Rizatriptan may be taken with or without food, but it is better to take it at a fixed time.

Common: • Dizziness • Dryness in mouth • Heaviness • Jaw pain • Nausea • Neck pain • Sleepiness • Throat pain • Weakness

[UNSAFE] Rizatriptan may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. You have been prescribed Rizatriptan for treatment of migraine headaches. Some tips that may help avoid a migraine attack: It may cause sleepiness. Don't drive or do anything that requires mental focus until you know how it affects you. Notify your doctor if your migraine occurs more often after starting the medication. Notify your doctor if you have stomach pain, headache, bloody diarrhoea or worsening high blood pressure. Inform your doctor if you have a history of heart disease or stroke. This medication does not prevent migraine attacks from happening.

History of MI, peripheral vascular disease, transient ishaemic attack, ischaemic heart disease or Prinzmetal's angina; uncontrolled hypertension; basilar or hemiplegic migraine; severe hepatic or renal impairment. Adolescent <18 yr.

Increased serum concentrations with propranolol. Increased risk of vasospastic reactions when used with ergotamine and methysergide. Concurrent use with SSRIs may increase risk of serotonin syndrome. Potentially Fatal: Concurrent use with or within 2 wk of stopping MAOI treatment.

[CAUTION] Caution is advised when consuming alcohol with Rizatriptan. Please consult your doctor.

[CONSULT YOUR DOCTOR] Rizatriptan may be unsafe to use during pregnancy. Although there are limited studies in humans, animal studies have shown harmful effects on the developing baby. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

[SAFE IF PRESCRIBED] Rizatriptan is probably safe to use during breastfeeding. Limited human data suggests that the drug does not represent any significant risk to the baby.

[CAUTION] Rizatriptan should be used with caution in patients with severe kidney disease. Dose adjustment of Rizatriptan may be needed. Please consult your doctor. Use of Rizatriptan is not recommended in patients with severe kidney disease. [CAUTION] Rizatriptan should be used with caution in patients with liver disease. Dose adjustment of Rizatriptan may be needed. Please consult your doctor.

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