Ryzodeg Penfill
100IU/mlRx৳ 1,500/unit
Pack: ৳ 1,500
৳ 1,500/unit
Pack: ৳ 1,500
At a glance
Insulin degludec + Insulin aspart 70/30 premixed is used to improve glycemic control in patients 1 year of age and older with diabetes mellitus.
Indications
- Improvement of glycemic control in patients 1 year of age and older with diabetes mellitus
Pharmacology
Insulin degludec and insulin aspart bind specifically to the human insulin receptor and result in the same pharmacological effects as human insulin. The blood glucose-lowering effect of insulin is due to the facilitated uptake of glucose following the binding of insulin to receptors on muscle and fat cells and to the simultaneous inhibition of glucose output from the liver.
Dosage
Adult Dose (Subcutaneous):
- Type 2 Diabetes (insulin-naïve): 10 units SC once daily
- Type 1 Diabetes: One third to one half of total daily insulin dose; 0.2-0.4 units/kg (for insulin-naïve patients)
- Conversion from other insulins: Same unit dose and injection schedule; for premix or self-mix insulin
- Dose adjustments: Based on fasting plasma glucose measurements; 3-4 days between increases
Child Dose: Safety and efficacy not established
Side effects
Side Effects:
- Hypoglycemia
- Allergic reactions
- Injection site reactions
- Lipodystrophy
- Pruritus
- Rash
- Edema
- Weight gain
Use in pregnancy
Use in Pregnancy: Category C; animal studies have shown adverse effect on fetus; no adequate human studies; potential benefits may warrant use despite potential risks.
Pregnancy Category: C — always consult a doctor before taking during pregnancy.
Precautions & warnings
Precautions:
- Hypoglycemia: Omission of meal or unplanned strenuous exercise may lead to hypoglycemia
- Hyperglycemia: Inadequate dosing and/or discontinuation of treatment may lead to hyperglycemia and potentially diabetic ketoacidosis
- Eye disorder: Intensification of insulin therapy with abrupt improvement may be associated with temporary worsening of diabetic retinopathy
- Avoidance of accidental mix-ups: Always check insulin label before each injection
- Ability to drive may be affected if blood sugar is too low or too high
- Rotate injection sites to prevent hard lumps
- Hypoglycemia may occur when taken with other antidiabetic medicines, alcohol or on skipping a meal
Overdose effects
No information on overdose; do not exceed recommended dose.
Storage conditions
Store in a cool & dry place, protected from light; keep out of reach of children.