Sunitix50mg

Sunitinib is used in the treatment of kidney cancer and gastrointestinal stromal tumor. Sunitinib can be taken with or without food, but try to have it at the same time every day to get the most benefits. Your doctor will decide what dose is necessary and how often you need to take it. This will depend on what you are being treated for and may change from time to time. You should take it exactly as your doctor has advised. Taking it in the wrong way or taking too much can cause very serious side effects. It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Nausea, vomiting, weakness and weight loss are some common side effects of this medicine. The doctor may advise for regular monitoring of blood pressure and thyroid gland function while taking this medicine. It may decrease blood sugar levels. In fact, the levels can decrease to the extent that the patient may faint. So, if you are diabetic then it is important to check your blood sugar levels regularly. Additionally, you should also consult the doctor if the dose of anti-diabetic medicines needs to be adjusted. This medicine may affect wound healing time, so be careful while shaving, cutting fingernails or using sharp objects. Before taking it, tell your doctor if you have heart disease, liver, or kidney problems or bleeding disorder. Many other medicines can affect, or be affected by, this medicine so let your healthcare team know all medications you are using. This medicine is not recommended during pregnancy or while breastfeeding. The use of effective contraception by both males and females during treatment is important to avoid pregnancy. Sunitinib is an anti-cancer medication. It works by binding and blocking certain cell surface protein (tyrosine kinase) responsible for the propagation of cancer growth. It also restricts the growth of new blood vessels within the tumor. This is how it prevents the proliferation of malignant cancers.

• Kidney cancer • Gastrointestinal stromal tumour

Multikinase inhibitor (including VEGF & PDGF receptor tyrosine kinases) some of which are implicated in tumor growth, angiogenesis, and metastasis.

Adult Dose: Hepatic Impairment Mild to moderate impairment: Dose adjustment not necessary for initial dose; monitor subsequent doses Severe impairment: Not studied Child Dose: Safety and efficacy not established Renal Dose: Renal Impairment No dose adjustment necessary

Take this medicine in the dose and duration as advised by your doctor. Do not chew, crush or break it. Sunitinib may be taken with or without food, but it is better to take it at a fixed time.

If you miss a dose of Sunitinib, skip it and continue with your normal schedule. Do not double the dose.

Common: • Nausea • Vomiting • Weakness • Rash • Abdominal pain • Indigestion • Discoloration of skin • Fatigue • Fever • Dry skin • High blood pressure • Diarrhea • Constipation • Painful blisters on hands and feet • Stomatitis (Inflammation of the mouth) • Hair discoloration • Pain in extremity • Back pain • Headache • Joint pain • Weight loss • Cough • Taste change • Breathlessness

[UNSAFE] Sunitinib may decrease alertness, affect your vision or make you feel sleepy and dizzy. Do not drive if these symptoms occur. Sunitinib is used for the treatment of thyroid cancer. Take it with or without food, preferably at the same time each day. Diarrhea may occur as a side effect. Drink plenty of fluids and inform your doctor if it doesn't stop or if you find blood in your stools. Use a reliable contraceptive method to prevent pregnancy while you are taking this medicine and for a month after you stop taking it. It may affect wound healing time. Be careful while shaving, cutting fingernails or toenails, or using sharp objects. Monitor your blood pressure regularly while taking this medication. Inform your doctor if you notice symptoms of very high blood pressure such as severe headache, confusion, problems with your eyesight, nausea or vomiting. Monitoring of thyroid gland function is required while taking this medicine. Inform your doctor if you notice symptoms of weight gain, dry skin, and hair. It may cause serious bleeding problem. Inform your doctor if you get headaches, stomach pain or if you notice blood in your urine or stools. Inform your doctor about the consumption of Sunitinib before going for surgical procedure. Do not take this medicine if you are pregnant, planning to conceive or breastfeeding.

Hypersensitivity, Renal impairment

Increased plasma conc w/ strong CYP3A4 inhibitors (eg ketoconazole, ritonavir, itraconazole, erythromycin, clarithromycin, grapefruit juice). Decreased plasma conc w/ strong CYP3A4 inducers [eg rifampin, dexamethasone, phenytoin, carbamazepine, phenobarb, St. John's wort (Hypericum perforatum)]. Anticoagulants eg warfarin, acenocoumarol (periodically monitor platelets, prothrombin time/INR & physical exam).

[CONSULT YOUR DOCTOR] It is not known whether it is safe to consume alcohol with Sunitinib. Please consult your doctor.

[CONSULT YOUR DOCTOR] Sunitinib is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. However, the doctor may rarely prescribe it in some life-threatening situations if the benefits are more than the potential risks. Please consult your doctor.

[UNSAFE] Sunitinib is unsafe to use during breastfeeding. Data suggests that the drug may cause toxicity to the baby.

[SAFE IF PRESCRIBED] Sunitinib is safe to use in patients with kidney disease. No dose adjustment of Sunitinib is recommended. [CAUTION] Sunitinib should be used with caution in patients with severe liver disease. Dose adjustment of Sunitinib may be needed. Please consult your doctor. Limited information is available on the use of Sunitinib in these patients. No dose adjustment is recommended in patients with mild to moderate liver disease.

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