Supraphen PLUS
500mg+100mg/100mlRx৳ 20/unit
Pack: ৳ 20
৳ 20/unit
Pack: ৳ 20
At a glance
Chloramphenicol 5% + Lidocaine Hydrochloride 1% Ear drops is a combination medicine used for the treatment of acute bacterial ear infections.
Indications
- Acute bacterial ear infections
- Otitis externa
- Aural otitis
Pharmacology
Chloramphenicol inhibits bacterial protein synthesis by binding to 50s subunit of the bacterial ribosome, thus preventing peptide bond formation by peptidyl transferase. It has both bacteriostatic and bactericidal action against H. influenzae, N. meningitidis and S. pneumoniae. Lidocaine is an amide type local anesthetic. It stabilises the neuronal membrane and inhibits Na ion movements, which are necessary for conduction of impulses. In the heart, lidocaine reduces depolarisation of the ventricles during diastole and automaticity in the His-Purkinje system. Duration of action potential and effective refractory period are also reduced.
Dosage
Adult Dose (Otic): Otitis externa/Aural otitis: Instill 2-3 drops into the ear 2-3 times daily.
Side effects
Side Effects:
- Ototoxicity (hearing impairment)
- Local irritation
- Allergic reactions
Use in pregnancy
Limited information is available regarding the use of Chloramphenicol 5% + Lidocaine Hydrochloride 1% Ear drops during pregnancy. Please consult your doctor.
Precautions & warnings
- Avoid prolonged use.
- Discontinue immediately if local hypersensitivity reactions occur.
- Do not use if you have a perforated ear drum.
- Caution required during pregnancy and lactation.
Overdose effects
Information on overdosage is not available. Consult a physician if overdose is suspected.
Storage conditions
Keep in a cool and dry place, away from light & keep out of the reach of children.