৳ 2.77/unit
Pack: ৳ 2.77
৳ 2.77/unit
Pack: ৳ 2.77
At a glance
Tinidazole is a 5-nitroimidazole antibiotic and antiprotozoal used for bacterial and parasitic infections. It eliminates infections by damaging the DNA of microorganisms.
Indications
- Bacterial vaginosis
- Anaerobic bacterial infections
- Prophylaxis of postoperative anaerobic infections
- H. pylori eradication (in peptic ulcer)
- Intestinal amoebiasis, hepatic amoebiasis
- Giardiasis
- Trichomoniasis
- Acute necrotising ulcerative gingivitis
Pharmacology
Tinidazole enters microorganisms and is reduced by ferredoxin, producing active intermediate compounds that damage DNA strands or inhibit DNA synthesis, causing microorganism death.
Dosage
Adult Dose (Oral):
- Bacterial vaginosis: 2 g single dose (or 2 g for 2 days, or 1 g/day for 5 days)
- Anaerobic infections: 2 g on day 1, then 1 g/day or 500 mg twice daily (5-6 days)
- Postoperative prophylaxis: 2 g single dose (12 hours before surgery)
- H. pylori: 500 mg twice daily (with clarithromycin and omeprazole for 7 days)
- Intestinal amoebiasis: 2 g/day (2-3 days)
- Hepatic amoebiasis: 1.5-2 g/day (3-6 days)
- Giardiasis/Trichomoniasis: 2 g single dose
Pediatric Dose (Oral):
- Intestinal amoebiasis (>3 years): 50-60 mg/kg/day (3 days); max 2 g/day
- Hepatic amoebiasis (>3 years): 50-60 mg/kg/day (5 days); max 2 g/day
- Giardiasis (>3 years): 50-75 mg/kg single dose; max 2 g/day
Side effects
Common Side Effects:
- Headache
- Dry mouth
- Nausea
- Metallic taste
Use in pregnancy
Use in Pregnancy: May be unsafe; animal studies show harmful effects; do not use in the 1st trimester; consult your doctor.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Do not consume alcohol (disulfiram-like reaction)
- Do not use in blood dyscrasias, organic neurologic disorders
- Do not use in the 1st trimester of pregnancy
- High doses or prolonged use increase risk of nerve damage
Overdose effects
No overdose information available; excessive doses may increase side effects; consult your doctor.
Storage conditions
Store in a cool and dry place, protected from light; keep out of reach of children.