৳ 10/unit
Pack: ৳ 100
৳ 10/unit
Pack: ৳ 100
At a glance
Tamoxifen is an anti-estrogen drug used for breast cancer treatment and reducing breast cancer risk in high-risk women. It blocks estrogen effects in breast tissue by binding to estrogen receptors.
Indications
- Breast cancer treatment (ER-positive)
- Breast cancer prevention in high-risk women
- Anovulatory infertility
Pharmacology
Tamoxifen competitively binds to estrogen receptors, blocking estrogen-dependent tumor cell growth. It decreases DNA synthesis and arrests cells in G0 and G1 phases of the cell cycle, reducing cell division. It also helps maintain bone mineral density in postmenopausal women.
Dosage
Adult Dose (Oral):
- Breast cancer: 20 mg/day (single or 2 divided doses); max 40 mg/day; adjuvant therapy for at least 5 years (up to 10 years recommended)
- Breast cancer prevention: 20 mg/day for 5 years
- Anovulatory infertility: 20 mg/day (days 2-5 of cycle); may increase to 40-80 mg/day
Side effects
Common Side Effects:
- Nausea, skin rash
- Hot flashes, hair thinning
- Vaginal discharge, edema
- Headache, light-headedness
Serious:
- DVT, pulmonary embolism (thromboembolic events)
- Endometrial cancer (monitor for vaginal bleeding)
- Hypercalcemia (in bone metastases)
Use in pregnancy
Use in Pregnancy: Highly unsafe (Category D); significant risk to developing baby; do not use; consult your doctor.
Pregnancy Category: X — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Do not use in history of DVT or pulmonary embolism
- Do not use in pregnancy and lactation
- Investigate any abnormal gynecological symptoms (vaginal bleeding)
- Birth control pills are less effective; use condoms
- Monitor liver function and calcium levels
Overdose effects
No specific antidote for overdose; provide symptomatic and supportive treatment.
Storage conditions
Store at 20-25°C, protected from light; keep out of reach of children.