৳ 21.49/unit
Pack: ৳ 601.72
৳ 21.49/unit
Pack: ৳ 601.72
At a glance
Tibolone is a synthetic steroid used for menopausal symptoms (hot flushes, vaginal dryness) and prevention of osteoporosis in postmenopausal women. It has estrogenic, progestogenic, and weak androgenic properties.
Indications
- Symptoms of natural or surgical menopause
- Prevention of postmenopausal osteoporosis (high-risk women)
Pharmacology
Tibolone is rapidly metabolized into three active metabolites. 3α-OH and 3β-OH metabolites activate estrogen receptors; δ4-isomer activates progesterone and androgen receptors. It reduces hot flushes at thermoregulatory centers, improves vaginal dryness and atrophy, prevents bone loss, and improves mood and libido.
Dosage
Adult Dose (Oral):
- Menopausal symptoms: 2.5 mg/day
- Postmenopausal osteoporosis prevention: 2.5 mg/day (5-10 years)
- Natural menopause: Start 12 months after last natural bleed
- Surgical menopause: Start immediately
Side effects
Common Side Effects:
- Vaginal bleeding or spotting (especially in the first months)
- Headache, migraine
- Edema, dizziness
- Pruritus, weight gain
- Nausea, abdominal pain
- Rash, depression
Use in pregnancy
Use in Pregnancy: Highly unsafe; discontinue immediately if pregnancy occurs; consult your doctor.
Pregnancy Category: X — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Do not use in history of breast cancer or estrogen-dependent tumors
- Do not use in undiagnosed vaginal bleeding or severe liver disease
- Do not use in pregnancy and lactation
- Do not use in history of cardiovascular or cerebrovascular disorders
- Regular breast and cervical smear examinations required
Overdose effects
Overdose may cause nausea, vomiting, vaginal bleeding; provide symptomatic treatment.
Storage conditions
Store in a cool and dry place, protected from light; keep out of reach of children.