৳ 100/unit
Pack: ৳ 100
৳ 100/unit
Pack: ৳ 100
At a glance
Tobramycin Sulphate is an aminoglycoside antibiotic used via inhalation for managing Pseudomonas aeruginosa infection in cystic fibrosis patients. It inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit.
Indications
- Management of Pseudomonas aeruginosa in patients with cystic fibrosis
Pharmacology
Tobramycin binds to the 30S ribosomal subunit, inhibiting bacterial protein synthesis. Inhaled tobramycin achieves high concentrations in the lungs, making it effective against Pseudomonas aeruginosa.
Dosage
Adult Dose (Inhalation):
- 300 mg ampoule every 12 hours inhaled from a suitable nebulizer for 28 days, then stop for 28 days; repeat in cycles of 28 days as needed
Pediatric Dose (>6 years):
- Same as adult dose
Side effects
Common Side Effects (>10%):
- Voice alteration (12.8%)
1-10%:
- Myalgia (4.7%)
- Laryngitis (4.3%)
- Tinnitus (3%)
- Epistaxis (3%)
Use in pregnancy
Use in Pregnancy: Unsafe; evidence of fetal risk; use only in life-threatening situations; consult your doctor.
Pregnancy Category: D — always consult a doctor before taking during pregnancy.
Precautions & warnings
- Caution in pre-existing renal and auditory/vestibular impairment
- Caution in dehydration, neuromuscular blockade, myasthenia gravis, parkinsonism
- Caution in neonates, elderly, and lactation
- Dose adjustment needed in renal impairment
Overdose effects
No overdose information available; excessive doses may cause nephrotoxicity or ototoxicity; provide symptomatic treatment.
Storage conditions
Store at 2-8°C in a refrigerator; do not freeze; protect from light; keep out of reach of children.