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At a glance

Tretinoin Topical is a form of vitamin A used to treat acne, smooth rough facial skin, reduce fine wrinkles, and treat pregnancy-related abdominal striae.

Indications
  • Acne
  • Pregnancy-related abdominal striae
  • Mottled hyperpigmentation
  • Photodamaged skin
  • Flat warts
  • Ichthyosis vulgaris
  • Keratosis follicularis
Pharmacology

Tretinoin is a trans-retinoic acid form of vitamin A. Topically, it decreases cohesiveness of follicular epithelial cells with decreased microcomedo formation. It stimulates mitotic activity and increases turnover of follicular epithelial cells, causing extrusion of comedones, papules and pustules.

Dosage

Adult Dose (Topical):

  • Acne vulgaris: Apply once at bedtime to affected area; therapeutic response may be seen after 6-8 weeks
  • Photodamaged skin: Apply a pea-sized amount to entire face once daily at night; therapeutic response may be seen after 6 months

Child Dose (Topical):

  • Acne vulgaris (over 12 years): Apply once at bedtime to affected area
Side effects

Common Side Effects:

  • Erythema (skin redness)
  • Skin irritation
  • Dry skin
  • Dry lips
  • Pale red skin
  • Increased sensitivity to light
Use in pregnancy

Use in Pregnancy: May be unsafe; animal studies show harmful effects; consult your doctor.

Pregnancy Category: D — always consult a doctor before taking during pregnancy.

Precautions & warnings
  • Avoid exposure to sunlight; use sunscreen or protective clothing
  • Avoid face waxing or laser treatment
  • Avoid tetracycline (e.g., doxycycline); may reduce tretinoin activity
  • Do not use if pregnant
  • Inform doctor if excessive skin dryness or sensitivity occurs
Overdose effects

Overdose is not applicable (topical application).

Storage conditions

Store in a cool and dry place, protected from light; keep out of reach of children.

Tretinoin Topical — see the full informationPharmacology, precautions, pregnancy, overdose and the rest on the generic page
⚠️ This information is for educational purposes only — not a substitute for medical advice. Consult a registered physician before taking any medicine.